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Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia.
MedLine Citation:
PMID:  21888567     Owner:  NLM     Status:  In-Data-Review    
Abstract Background: Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B. cepacia complex has been associated with increased morbidity and mortality in intensive care unit patients. However, in our literature search, we could not find studies on risk factors for mortality in patients with B. cepacia complex bacteraemia. Therefore, we investigated risk factors for mortality in B. cepacia complex bacteraemia. Methods: Clinical characteristics and laboratory parameters of 27 patients with 1 or more blood cultures positive for B. cepacia complex from January 2006 to October 2010 in Severance Hospital, Yonsei University College of Medicine, Korea were retrospectively analyzed. The main outcome measure was overall 28-day mortality. Appropriate initial empirical antimicrobial use was defined as administration of agent(s) to which the organism was susceptible within 24 h of obtaining blood for culture. Results: The overall 28-day mortality rate was 41% (11/27). In univariate analysis, underlying diabetes mellitus (p = 0.033), inappropriate initial empirical antimicrobial therapy (p = 0.033), and an elevated Sequential Organ Failure Assessment (SOFA) score (p = 0.002) were significantly associated with mortality. In multivariate analysis, inappropriate initial empirical antimicrobial therapy and an elevated SOFA score were independent risk factors for increased mortality (p = 0.032 and p = 0.028, respectively). Conclusions: An elevated SOFA score and inappropriate initial empirical antimicrobial therapy were significantly associated with adverse outcome in patients with B. cepacia complex bacteraemia.
Nam Su Ku; Sang Hoon Han; Chang Oh Kim; Ji-Hyeon Baek; Su Jin Jeong; Sung Joon Jin; Jun Yong Choi; Young Goo Song; June Myung Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  43     ISSN:  1651-1980     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  792-7     Citation Subset:  IM    
Department of Internal Medicine, Yonsei University College of Medicine , Seoul , Korea.
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