Document Detail

Risk factors of mortality in meconium aspiration syndrome: review of 314 cases.
MedLine Citation:
PMID:  15264703     Owner:  NLM     Status:  MEDLINE    
Meconium aspiration syndrome (MAS) is a common severe respiratory disease in full-term infants. To investigate the risk factors for mortality of MAS, a retrospective chart-review study of MAS was conducted from 1995 to 2001. All cases of MAS were included except cases of cyanotic congenital heart disease or congenital fetal anomaly. Prenatal, perinatal and postnatal risk factors of mortality were recorded. The risk factors were compared between surviving and deceased cases. There were 314 cases of MAS during the seven years. Total mortality rate was 4.8% (15/314); this did not change significantly during these years. Risk factors of mortality by univariate analysis were: outborn babies, resuscitation before admission, first born baby, low pH, high oxygen index (OI), high alveolar-arterial oxygen tension gradient (AaDO2) at admission, high OI and AaDO2 at 2 hours after admission, shock, pneumothorax, asphyxia, pulmonary hemorrhage, persistent pulmonary hypertension of newborn (PPHN), and renal failure. Logistic regression analysis showed asphyxia, pneumothorax and PPHN are the most important risk factors of mortality in MAS. How to diminish these events is the key point for reducing the mortality rate of MAS.
Hung-Chih Lin; Bai-Horng Su; Tsung-Wen Lin; Ching-Tien Peng; Chang-Hai Tsai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi     Volume:  45     ISSN:  1608-8115     ISO Abbreviation:  Acta Paediatr Taiwan     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-07-21     Completed Date:  2004-08-31     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100958202     Medline TA:  Acta Paediatr Taiwan     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  30-4     Citation Subset:  IM    
Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
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MeSH Terms
Apgar Score
Birth Weight
Gestational Age
Infant, Newborn
Logistic Models
Meconium Aspiration Syndrome / epidemiology,  mortality*
Medical Records / statistics & numerical data
Respiratory Function Tests
Retrospective Studies
Risk Factors
Survival Rate
Taiwan / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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