Document Detail

Risk factors and medical management of vasospasm after subarachnoid hemorrhage.
MedLine Citation:
PMID:  20380975     Owner:  NLM     Status:  MEDLINE    
Vasospasm is a major cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage. This article reviews the risk factors for vasospasm; the various methods for diagnosing vasospasm including the conventional 4-vessel angiography, computed tomographic angiography, and computed tomographic perfusion; the methods to detect vasospasm before clinical onset (including transcranial Doppler ultrasonography); and the recent emergence of multimodality monitoring. A discussion of medical treatment options in the setting of vasospasm is also included; the prophylactic use of "neuroprotectants" such as nimodipine, statins, and magnesium and the role of hemodynamic augmentation in vasospasm amelioration, including the use of inotropic support in addition to traditional triple-H therapy, are discussed.
Christos Lazaridis; Neeraj Naval
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery clinics of North America     Volume:  21     ISSN:  1558-1349     ISO Abbreviation:  Neurosurg. Clin. N. Am.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9008004     Medline TA:  Neurosurg Clin N Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-64     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Neurology, Neurosciences Intensive Care Unit, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 428, Charleston, SC 29425, USA.
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MeSH Terms
Cerebral Angiography / methods,  trends
Cerebral Arteries / pathology,  radiography*,  ultrasonography
Cerebrovascular Circulation / physiology
Diagnostic Imaging / methods*,  trends
Neuroprotective Agents / pharmacology,  therapeutic use
Risk Factors
Subarachnoid Hemorrhage / complications*
Tomography, X-Ray Computed / methods,  trends
Ultrasonography, Doppler, Transcranial
Vasospasm, Intracranial / diagnosis*,  physiopathology*,  therapy
Reg. No./Substance:
0/Neuroprotective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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