Document Detail

Risk factors of meconium aspiration syndrome developing into persistent pulmonary hypertension of newborn.
MedLine Citation:
PMID:  15624365     Owner:  NLM     Status:  MEDLINE    
Clinical experience indicates that persistent pulmonary hypertension of the newborn (PPHN) is one of the major causes of death in infants with meconium aspiration syndrome (MAS). We aimed to investigate the risk factors associated with MAS which lead to PPHN in order to search for ways to reduce the mortality associated with MAS. From 1995 to 2003, we conducted a retrospective study of infants with MAS at the China Medical University Hospital. We compared the risk factors associated with MAS, including pattern of fetal heart beat, mode of delivery, apgar score, sex, gestational age, birth body weight, in born or out born infants, resuscitation before admission, first pH at admission, asphyxia, surfactant usage, pneumothorax, pulmonary hemorrhage and shock before the diagnosis of PPHN between PPHN and non PPHN infants. During the nine-year study, 362 infants with MAS were enrolled. There were 64 infants with (17.7%) PPHN and 298 infants without PPHN. According to univariant analysis, the significant risk factors associated with MAS which lead to PPHN were out born infant (p=0.007), change of fetal heart beat pattern (p=0.0001), resuscitation before admission (p=0.0001), low pH (p=0.002), asphyxia (p<0.0001), shock (p<0.0001), pneumothorax (p=0.0004), and pulmonary hemorrhage (p<0.0002). Based on the results of logistic regression analysis, the risk factors were pneumothorax (p=0.04, odds ratio: 2.34), change of fetal heart beat pattern (p=0.02, odds ratio: 2.37) and asphyxia (p=0.001, odds ratio: 5.48). We conclude that pneumothorax, change of fetal heart beat pattern and asphyxia are the most important risk factors associated with MAS which lead to the development of PPHN. Avoidance of asphyxia and pneumothorax might be the key to reduce the incidence of PPNH and mortality rate of MAS.
Te-Kuei Hsieh; Bai-Hong Su; An-Chyi Chen; Tsung-Wen Lin; Chang-Hai Tsai; Hung-Chih Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi     Volume:  45     ISSN:  1608-8115     ISO Abbreviation:  Acta Paediatr Taiwan     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-12-30     Completed Date:  2005-04-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100958202     Medline TA:  Acta Paediatr Taiwan     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Department of Pediatrics, Hsin Chu General Hospital, Hsinchu, Taiwan.
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MeSH Terms
Apgar Score
Asphyxia Neonatorum / etiology
Body Weight
Gestational Age
Hypertension, Pulmonary / epidemiology,  etiology*
Infant, Newborn
Meconium Aspiration Syndrome / complications*
Retrospective Studies
Risk Factors
Sex Factors
Taiwan / epidemiology
Comment In:
Acta Paediatr Taiwan. 2004 Jul-Aug;45(4):197-9   [PMID:  15624362 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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