| Risk factors for lower extremity amputation in diabetic foot disease categorized by Wagner classification. | |
| | |
MedLine Citation:
|
PMID: 22115502 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: To elucidate the risk factors for lower extremity amputation (LEA) in patients of diabetic foot disease with different Wagner gradings. METHODS: This study was conducted in a multidisciplinary diabetic foot care center. Demographic characteristics, laboratory data, disease history, ankle brachial pressure index (ABI) and Wagner classification were considered as independent variables to predict the therapeutic outcome (major LEA, minor LEA, and non-amputation). Risk factors for LEA in different Wagner grades were further analyzed. Multivariate stepwise ordinal logistic regression was performed. RESULTS: Of 789 study subjects, 19.9% received major LEA and 22.9% received minor LEA. Higher Wagner grade, lower ABI, serum albumin and hemoglobin, and elevated white blood cell (WBC) count were significantly associated with an increased risk of LEA. When stratified by Wagner classification, most of the above predictors and estimated glomerular filtration (eGFR) were detected only in grade 3. While in grades 2 and 4, WBC count was identified as primary predictor positively associated with an increased risk of LEA. CONCLUSIONS: Wagner classification remarkably influenced the potential risk factors for LEA, showing different predictors in different grades. The traditionally recognized predictors for diabetic foot amputation such as lower ABI, albumin or eGFR were almost exclusively found in patients with Wagner grade 3. |
| | |
Authors:
|
Jui-Hung Sun; Jir-Shiong Tsai; Chung-Huei Huang; Chia-Hung Lin; Hui-Mei Yang; Yi-Sheng Chan; Sheng-Hwu Hsieh; Brend Ray-Sea Hsu; Yu-Yao Huang |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: - ISSN: 1872-8227 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, 5 Fusing St., Gueishan Township, Taoyuan County 333, Taiwan, ROC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications.
Next Document: Challenges in real-life diabetes translation research: Early lessons from BRIDGES projects.