Document Detail

Risk factors leading to reduced bone mineral density in hemodialysis patients with metabolic syndrome.
MedLine Citation:
PMID:  20446786     Owner:  NLM     Status:  MEDLINE    
Although metabolic syndrome (MS) is associated with low bone mineral density (BMD) in the general population, it is unknown whether similar associations exist in patients with chronic kidney disease. We investigated risk factors that can lead to low BMD values in hemodialysis patients with MS according to the diagnostic criteria set by International Diabetes Federation (IDF) in this study. A total of 64 patients with MS undergoing hemodialysis and 60 hemodialysis patients who were matched in terms of age, gender, and hemodialysis duration without MS were enrolled in the study. BMD was measured at lumbar vertebra (LV) and femur neck (FN) by performing dual-energy X-ray absorptiometry (DEXA). LV and/or FN-BMD results revealed that, of the hemodialysis patients with MS, 45% had osteoporosis and 48% had osteopenia. On the other hand, of the hemodialysis patients without MS, 42% had osteoporosis and 52% had osteopenia. Low BMD values were observed to be correlated negatively with age, hemodialysis period, and parathormone (PTH) both in the group with MS and in the group without MS. Height, weight, BMI, calcium, phosphorus, alkaline phosphatase, heparin, and vitamin D therapy and urea reduction ratio were not established to be correlated with BMD.
Dogan Nasir Binici; Nurettin Gunes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  32     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-74     Citation Subset:  IM    
Department of Internal Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey.
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MeSH Terms
Absorptiometry, Photon
Age Factors
Biological Markers / blood
Blood Glucose / analysis
Bone Density*
Bone Diseases, Metabolic / etiology*,  radiography
Chi-Square Distribution
Lipids / blood
Logistic Models
Metabolic Syndrome X / complications*
Middle Aged
Osteoporosis / etiology*,  radiography
Renal Dialysis / adverse effects*
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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