Document Detail

Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus.
MedLine Citation:
PMID:  17011313     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study aimed to investigate risk factors for the development of intussusception in infants in a developing country with a suspected high incidence and in a developed country with a low incidence. STUDY DESIGN: A prospective case-control study of infants <2 years of age with idiopathic intussusception confirmed by air enema or surgery was conducted at the National Hospital of Paediatrics (NHP), Vietnam (n = 533) and the Royal Children's Hospital (RCH), Australia (n = 51). Diagnosis was validated in a subset (84% NHP; 67% RCH) by an independent blinded radiologist. Risk factor assessment was performed using a standardized questionnaire. Stool specimens were assayed for bacterial, viral, and parasitic agents. RESULTS: The incidence of intussusception in Vietnam was 302/100,000 in infants <1 year of age (95% CI: 258-352), substantially higher than in Australia (71/100,000). A strong association with adenovirus infection was observed at both sites (cases positive at NHP: 34%, OR 8.2; cases positive at RCH: 40%, OR 44). No association was identified between intussusception and rotavirus, other enteric pathogens, oral polio vaccine, feeding practices, or living conditions. CONCLUSIONS: The incidence of intussusception in infants was markedly higher in Vietnam than in Australia. A strong association between adenovirus infection and intussusception was identified at both sites suggesting that adenovirus may play a role in the etiology of intussusception.
Julie E Bines; Nguyen Thanh Liem; Frances A Justice; Tran Ngoc Son; Carl D Kirkwood; Margaret de Campo; Peter Barnett; Ruth F Bishop; Roy Robins-Browne; John B Carlin;
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  149     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-60     Citation Subset:  AIM; IM    
Department of Gastroenterology and Clinical Nutrition, Emergency Medicine, Microbiology, Clinical Epidemiology and Biostatistics Unit, Royal Children's Hospital, Parkville, Australia.
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MeSH Terms
Adenovirus Infections, Human / complications*
Case-Control Studies
Intussusception / virology*
Prospective Studies
Risk Factors
Rotavirus Infections
Comment In:
J Pediatr. 2006 Oct;149(4):448-51   [PMID:  17011312 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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