Document Detail

Risk factors for intraventricular hemorrhage in a birth cohort of 3721 premature infants.
MedLine Citation:
PMID:  10875094     Owner:  NLM     Status:  MEDLINE    
AIMS: In our study we determined possible risk factors for intraventricular hemorrhage grade III to IV (IVH) based on a regional German neonatal data base and tried to build a logistic-regression model to predict the risk of IVH according to gestational age. MATERIALS: We identified 3721 premature infants, 22 to 36 completed weeks of gestational age, born from 1994 through 1997. 136 (3.7%) IVH were diagnosed sonographically. 60 (44%) infants with IVH died. We examined the following variables as risk factors for IVH: gestational age, sex, blood pH of 7.2 or less, body temperature of 35 degrees C or less, multiple birth, small-for-gestational age, intubation after birth, transport to another hospital. RESULTS: In the full logistic regression model sex, blood pH of 7.2 or less, multiple birth, and small-for-gestational age were not associated with a significant risk of IVH. Body temperature of 35 degrees C or less was associated with an increased risk of IVH (adjusted odds ratio, 1.92; 95% confidence interval, 1.09 to 3.40). Intubation after birth increased the risk of IVH in neonates under 28 weeks of gestational age (OR, 3.72; 95% CI, 1.65 to 8.38) only to a moderate extent, but significantly in neonates 32 to 36 weeks of gestational age (OR, 16.51; 95% CI: 7.35 to 36.18). The risk of IVH was mainly related to gestational age. Neonates delivered before 28 weeks of gestation (OR, 75.72; 95% CI, 46.14 to 124.30) faced the highest risk of IVH. Transport to another hospital was connected with an increased risk of IVH regardless of gestational age (adjusted OR, 1.95; 95% CI, 1.07 to 2.56). CONCLUSION: The frequency of IVH could be reduced significantly, if extremely premature infants, the vast majority of patients suffering from IVH, did not have to be transferred postnatally to another hospital.
M Gleissner; G Jorch; S Avenarius
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  28     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2000  
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  104-10     Citation Subset:  IM    
Zentrum für Kinderheilkunde, Otto-von-Guericke Universität Magdeburg, Germany.
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MeSH Terms
Birth Weight
Cerebral Hemorrhage / epidemiology*,  etiology
Cohort Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Logistic Models
Odds Ratio
Risk Factors
Transportation of Patients

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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