| Risk factors for intrahepatic cholangiocarcinoma: association between metformin use and reduced cancer risk. | |
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MedLine Citation:
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PMID: 23055147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The associations between diabetes, smoking, obesity, and intrahepatic cholangiocarcinoma (ICC) risk remain inconclusive. Metformin is purportedly associated with a reduced risk for various cancers. This case-control study evaluated risk factors for ICC and explored the effects of metformin on ICC risk in a clinic/hospital-based cohort. ICC patients observed at the Mayo Clinic (Rochester, MN) between January 2000 and May 2010 were identified. Age, sex, ethnicity, and residential area-matched controls were selected from among Mayo Clinic Biobank participants. The associations between potential factors and ICC risk were determined. Six hundred and twelve cases and 594 controls were identified. Factors associated with increased ICC risk included biliary tract diseases (adjusted odds ratio [AOR]: 81.8; 95% confidence interval [CI]: 11.2-598.8; P < 0.001), cirrhosis (AOR, 8.0; 95% CI: 1.8-36.5; P = 0.007), diabetes (AOR, 3.6; 95% CI: 2.3-5.5; P < 0.001), and smoking (AOR, 1.6; 95% CI: 1.3-2.1; P < 0.001). Compared to diabetic patients not treated with metformin, the odds ratio (OR) for ICC for diabetic patients treated with metformin was significantly decreased (OR, 0.4; 95% CI: 0.2-0.9; P = 0.04). Obesity and metabolic syndrome were not associated with ICC. CONCLUSION: This study confirmed diabetes and smoking as independent risk factors for ICC. A novel finding was that treatment with metformin was significantly associated with a 60% reduction in ICC risk in diabetic patients. |
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Authors:
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Roongruedee Chaiteerakij; Ju Dong Yang; William S Harmsen; Seth W Slettedahl; Teresa A Mettler; Zachary S Fredericksen; W Ray Kim; Gregory J Gores; Rosebud O Roberts; Janet E Olson; Terry M Therneau; Lewis R Roberts |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-12-12 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 57 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-06 Completed Date: 2013-04-04 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 648-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Association for the Study of Liver Diseases. |
Affiliation:
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Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bile Duct Neoplasms / etiology Case-Control Studies Cholangiocarcinoma / etiology*, prevention & control Diabetes Complications / prevention & control Diabetes Mellitus / drug therapy* Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Hyperlipidemias / drug therapy Liver Neoplasms / etiology*, prevention & control Male Metformin / therapeutic use* Middle Aged Obesity / complications Regression Analysis Risk Factors Smoking / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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CA100882/CA/NCI NIH HHS; CA128633/CA/NCI NIH HHS; CA15083/CA/NCI NIH HHS; CA165076/CA/NCI NIH HHS; P30 DK084567/DK/NIDDK NIH HHS; P30DK084567/DK/NIDDK NIH HHS; R01 CA165076/CA/NCI NIH HHS; R21 CA128633/CA/NCI NIH HHS; R56 CA100882/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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