Document Detail

Risk factors for in-stent restenosis after vertebral ostium stenting.
MedLine Citation:
PMID:  18426264     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine whether vascular risk factors, underlying vessel diameter, and/or the type of stent affect restenosis rates for vertebral ostium stents. METHODS: A single-center retrospective analysis was conducted of 44 patients (31 men; mean age 61 years, range 32-81) who underwent stenting of 48 ostial lesions in the vertebral arteries between 1999 and 2005. Only patients who underwent angiographic follow-up were included in the analysis. Cox regression analysis was utilized for risk factor association with binary restenosis (> or =50% versus <50%). Stent types and stent categories were compared for differences in binary restenosis rates and lumen gain at follow-up angiography. RESULTS: Twenty-three (48%) of 48 lesions had > or =50% stenosis at a mean follow-up of 7.7 months. Cigarette smoking was associated with higher binary restenosis rates (p=0.025), while hypertension, diabetes, hyperlipidemia, history of neck radiation, and known coronary artery and/or peripheral vascular disease were not. Reduced binary restenosis rates and improved lumen gain were seen in cobalt chromium balloon-expandable stents compared to non-cobalt chromium stents (p=0.002 and p=0.002, respectively), stainless steel balloon-expandable stents (p=0.005 and p=0.005), and the S670 stent (p=0.069 and p=0.069). The size of stent used was not associated with risk of restenosis (p=0.756). CONCLUSIONS: Cobalt chromium stents were associated with reduced restenosis, while smoking was associated with increased restenosis risk.
Robert A Taylor; Farhan Siddiq; M Fareed K Suri; Coleman O Martin; Minako Hayakawa; John C Chaloupka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists     Volume:  15     ISSN:  1526-6028     ISO Abbreviation:  J. Endovasc. Ther.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896915     Medline TA:  J Endovasc Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
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MeSH Terms
Aged, 80 and over
Arterial Occlusive Diseases / therapy*
Graft Occlusion, Vascular / etiology*
Middle Aged
Proportional Hazards Models
Retrospective Studies
Risk Factors
Smoking / adverse effects
Treatment Outcome
Vertebral Artery*
Reg. No./Substance:
7440-47-3/Chromium; 7440-48-4/Cobalt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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