Document Detail

Risk factors in retinopathy of prematurity. a multivariate statistical analysis.
MedLine Citation:
PMID:  10720918     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze risk factors in retinopathy of prematurity (ROP). PATIENTS AND METHODS: Four hundred forty-seven surviving very-low-birth-weight infants (birth weight </=1,500 g) were enrolled in a retrospective study. Clinical data underwent multivariate analysis using stepwise logistic forward regression. RESULTS: For 402 of the babies a complete dataset of 38 possible risk factors was available. Multivariate analysis showed 10 factors to be independently significant variables. Low birth weight, low gestational age, artificial ventilation for more than 7 days, high volume of blood transfusion and surfactant therapy were risk factors associated with higher rates of ROP. Necrotizing enterocolitis, maternal pre-eclampsia, lung maturation by antepartum betamethasone application, vitamin E and phototherapy were accompanied by a lower incidence of ROP. CONCLUSIONS: This study confirms several risk factors recognized by previous statistical analysis. In addition, this study reveals maternal pre-eclampsia, which is associated with chronic intrauterine stress, as a statistically independent factor and as having an influence on the incidence of ROP.
V Seiberth; O Linderkamp
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde     Volume:  214     ISSN:  0030-3755     ISO Abbreviation:  Ophthalmologica     Publication Date:  2000  
Date Detail:
Created Date:  2000-05-08     Completed Date:  2000-05-08     Revised Date:  2007-09-17    
Medline Journal Info:
Nlm Unique ID:  0054655     Medline TA:  Ophthalmologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Ophthalmology, Klinikum Mannheim, Faculty for Clinical Medicine of the University of Heidelberg, Mannheim, Germany.
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MeSH Terms
Germany / epidemiology
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Multivariate Analysis
Retinopathy of Prematurity / epidemiology*,  etiology
Retrospective Studies
Risk Factors

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