Document Detail


Risk factors for impaired gonadal function in female Hodgkin lymphoma survivors: final analysis of a retrospective multicenter joint study from Italian and Brazilian Institutions.
MedLine Citation:
PMID:  23027689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hodgkin lymphoma (HL) is one of the most common types of cancer in the young and one of the most curable forms of cancer. Therefore, there has been an increasing interest in the study of long-term morbidities. The aims of the present study were to evaluate the prevalence and risk factors for impaired gonadal function in a retrospective cohort of 238 HL female survivors from Italy and Brazil and to analyse the role of oral contraceptives (OC) and GnRH-analogues. Besides data collection from HL databases, a specific questionnaire was administered to collect data on gonadal function. The median age at diagnosis was 25 years and the median follow-up was 7 years. Overall, 25% of the patients developed impaired gonadal function. Older age at diagnosis, front-line therapies containing alkylating agents and more than one treatment were independent risk factors, whereas the use of OC or GnRH-a reduced independently the risk of impaired gonadal function. The fertility rate among fertile survivors was low when compared with the general population. We confirmed that older age, type of front-line chemotherapy and a higher number of therapies are associated with gonadal function impairment in terms of infertility and premature menopause in female HL survivors. Also, the use of GnRH-a or OC was independently identified as a protective factor. Further prospective studies are needed to better understand the barriers to parenthood in HL survivors.
Authors:
Simona Falorio; Irene Biasoli; Stefano Luminari; Giovanni Quintana; Maurizio Musso; Matteo Dell'olio; Maria Rosaria Specchia; Nicola di Renzo; Marina Cesaretti; Gabriele Buda; Daniele Vallisa; Donato Mannina; Alessandro Andriani; Carlos Sérgio Chiattone; Márcia Torresan Delamain; Cármino A de Souza; Nelson Spector; Francesco Angrilli; Massimo Federico
Related Documents :
23486849 - Psychometric properties of the greek version of the test of performance strategies-comp...
22928159 - Evolution of a level i trauma system: changes in injury mechanism and its impact in the...
24334739 - Driven apart: the evolution of ploidy differences between the sexes under antagonistic ...
23396589 - Comprehensive management of presbycusis: central and peripheral.
24350929 - Ageing, longevity, exceptional longevity and related genetic and non genetics markers: ...
24937629 - Category-specific face prototypes are emerging, but not yet mature, in 5-year-old child...
12426429 - Longitudinal selectivity in aging populations: separating mortality-associated versus e...
2336069 - Mutagenicity studies on paracetamol in human volunteers. iii. cytokinesis block micronu...
8274179 - Nutritional status in chronically alcoholic men from the middle socioeconomic class and...
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Hematological oncology     Volume:  31     ISSN:  1099-1069     ISO Abbreviation:  Hematol Oncol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-09-16     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brazil
Contraceptives, Oral
Female
Fertility Preservation
Hodgkin Disease / physiopathology*,  therapy
Humans
Infertility / etiology*
Italy
Ovary / physiopathology*
Retrospective Studies
Risk Factors
Survival Analysis
Young Adult
Chemical
Reg. No./Substance:
0/Contraceptives, Oral
Comments/Corrections
Erratum In:
Hematol Oncol. 2013 Spe;31(3):167

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Impact of Stressor Patterns on Clinical Features in Patients With Tako-tsubo Cardiomyopathy: Exp...
Next Document:  Stability of T cell phenotype and functional assays following heparinized umbilical cord blood colle...