Document Detail

Risk factors for impaired gonadal function in female Hodgkin lymphoma survivors: final analysis of a retrospective multicenter joint study from Italian and Brazilian Institutions.
MedLine Citation:
PMID:  23027689     Owner:  NLM     Status:  MEDLINE    
Hodgkin lymphoma (HL) is one of the most common types of cancer in the young and one of the most curable forms of cancer. Therefore, there has been an increasing interest in the study of long-term morbidities. The aims of the present study were to evaluate the prevalence and risk factors for impaired gonadal function in a retrospective cohort of 238 HL female survivors from Italy and Brazil and to analyse the role of oral contraceptives (OC) and GnRH-analogues. Besides data collection from HL databases, a specific questionnaire was administered to collect data on gonadal function. The median age at diagnosis was 25 years and the median follow-up was 7 years. Overall, 25% of the patients developed impaired gonadal function. Older age at diagnosis, front-line therapies containing alkylating agents and more than one treatment were independent risk factors, whereas the use of OC or GnRH-a reduced independently the risk of impaired gonadal function. The fertility rate among fertile survivors was low when compared with the general population. We confirmed that older age, type of front-line chemotherapy and a higher number of therapies are associated with gonadal function impairment in terms of infertility and premature menopause in female HL survivors. Also, the use of GnRH-a or OC was independently identified as a protective factor. Further prospective studies are needed to better understand the barriers to parenthood in HL survivors.
Simona Falorio; Irene Biasoli; Stefano Luminari; Giovanni Quintana; Maurizio Musso; Matteo Dell'olio; Maria Rosaria Specchia; Nicola di Renzo; Marina Cesaretti; Gabriele Buda; Daniele Vallisa; Donato Mannina; Alessandro Andriani; Carlos Sérgio Chiattone; Márcia Torresan Delamain; Cármino A de Souza; Nelson Spector; Francesco Angrilli; Massimo Federico
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Hematological oncology     Volume:  31     ISSN:  1099-1069     ISO Abbreviation:  Hematol Oncol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-09-16     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Contraceptives, Oral
Fertility Preservation
Hodgkin Disease / physiopathology*,  therapy
Infertility / etiology*
Ovary / physiopathology*
Retrospective Studies
Risk Factors
Survival Analysis
Young Adult
Reg. No./Substance:
0/Contraceptives, Oral
Erratum In:
Hematol Oncol. 2013 Spe;31(3):167

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