Document Detail


Risk factors for human immunodeficiency virus infection among blood donors in Sao Paulo, Brazil, and their relevance to current donor deferral criteria.
MedLine Citation:
PMID:  17381618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The objective of this study was to investigate risk factors of human immunodeficiency virus (HIV)-seropositive blood donors in Brazil and to determine if current donor deferral criteria are appropriate. STUDY DESIGN AND METHODS: Demographic and behavioral data among cases with confirmed HIV seropositivity (n = 272) were compared with those who had a false-positive serology (n = 468) between January 1999 and December 2003 in a case-control analysis with logistic regression. RESULTS: Risk factors that should have resulted in predonation deferral were reported by 48.9 percent of HIV-positive and 9.4 percent of false-positive donors. In multivariate analysis, male cases were significantly more likely to report male-male sex (adjusted odds ratio [AOR], 26.2; 95% confidence interval [CI], 7.8-87.4), a previous sexually transmitted disease diagnosis (AOR, 3.2; 95% CI, 1.5-6.9), exchanging money for sex (AOR, 2.1; 95% CI, 1.0-4.2), and at least two partners in the past 12 months (AOR, 2.3; 95% CI, 1.4-3.6). HIV-positive male donors were also more likely to be reactive for the presence of hepatitis C virus antibody (AOR, 4.0; 95% CI, 1.3-12.0) and hepatitis B virus core antibody (AOR, 3.8; 95% CI, 1.9-7.7). Female cases were more likely to report an intravenous drug user partner (AOR, 12.4; 95% CI, 1.3-120.2), a sexual partner with multiple sex partners or who had a history of sex with a sex worker (AOR, 13.0; 95% CI, 2.7-63.2), and at least two partners in the past 12 months (AOR, 2.2; 95% CI, 1.0-5.3). CONCLUSION: A substantial number of HIV-infected donors reported a risk factor that could have been identified in the predonation screening. Male-male sexual behavior was still the strongest determinant of HIV status in the studied population.
Authors:
Cesar de Almeida Neto; William McFarland; Edward L Murphy; Sanny Chen; Fatima Aparecida Hangai Nogueira; Alfredo Mendrone; Nanci Alves Salles; Dalton Alencar Fischer Chamone; Ester Cerdeira Sabino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transfusion     Volume:  47     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-09-04     Revised Date:  2009-05-14    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-14     Citation Subset:  IM    
Affiliation:
Pro-Blood Foundation, Blood Center of Sao Paulo, Brazil. cesarnt@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Blood Donors / legislation & jurisprudence,  statistics & numerical data*
Blood Transfusion / standards*,  statistics & numerical data
Brazil
Case-Control Studies
Confidence Intervals
Female
HIV Infections / blood*,  diagnosis
HIV Seropositivity / blood,  diagnosis
Homosexuality, Male / statistics & numerical data
Humans
Male
Mass Screening / methods
Middle Aged
Odds Ratio
Risk Factors
Sexual Behavior / statistics & numerical data
Sexual Partners
Sexually Transmitted Diseases / blood,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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