Document Detail

Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean Osteoporosis Study.
MedLine Citation:
PMID:  10367029     Owner:  NLM     Status:  MEDLINE    
The aims of this study were to identify risk factors for hip fracture in men aged 50 years or more. We identified 730 men with hip fracture from 14 centers from Portugal, Spain, France, Italy, Greece and Turkey during the course of a prospective study of hip fracture incidence and 1132 age-stratified controls selected from the neighborhood or population registers. The questionnaire examined aspects of work, physical activity past and present, diseases and drugs, height, weight, indices of co-morbidity and consumption of tobacco, alcohol, calcium, coffee and tea. Significant risk factors identified by univariate analysis included low body mass index (BMI), low sunlight exposure, a low degree of recreational physical activity, low consumption of milk and cheese, and a poor mental score. Co-morbidity including sleep disturbances, loss of weight, impaired mental status and poor appetite were also significant risk factors. Previous stroke with hemiplegia, prior fragility fractures, senile dementia, alcoholism and gastrectomy were associated with significant risk, whereas osteoarthrosis, nephrolithiasis and myocardial infarction were associated with lower risks. Taking medications was not associated with a difference in risk apart from a protective effect with the use of analgesics independent of co-existing osteoarthrosis and an increased risk with the use of anti-epileptic agents. Of the potentially 'reversible' risk factors, BMI, leisure exercise, exposure to sunlight and consumption of tea and alcohol and tobacco remained independent risk factors after multivariate analysis, accounting for 54% of hip fractures. Excluding BMI, 46% of fractures could be explained on the basis of the risk factors sought. Of the remaining factors low exposure to sunlight and decreased physical activity accounted for the highest attributable risks (14% and 9% respectively). The use of risk factors to predict hip fractures had relatively low sensitivity and specificity (59.6% and 61.0% respectively). We conclude that lifestyle factors are associated with significant differences in the risk of hip fracture. Potentially remediable factors including a low degree of physical exercise and a low BMI account for a large component of the total risk.
J Kanis; O Johnell; B Gullberg; E Allander; L Elffors; J Ranstam; J Dequeker; G Dilsen; C Gennari; A L Vaz; G Lyritis; G Mazzuoli; L Miravet; M Passeri; R Perez Cano; A Rapado; C Ribot
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  9     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  1999  
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  45-54     Citation Subset:  IM    
WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK.
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MeSH Terms
Aged, 80 and over
Alcohol Drinking / epidemiology
Body Height
Body Mass Index
Body Weight
Calcium, Dietary / administration & dosage
Europe / epidemiology
Hip Fractures / epidemiology*
Middle Aged
Risk Factors
Smoking / epidemiology
Reg. No./Substance:
0/Calcium, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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