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Risk factors for hidradenitis suppurativa: a pilot study.
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PMID:  23197222     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The hidradenitis suppurativa is a chronic debilitating inflammatory disease whose etiology is not fully understood. We conducted a pilot case-control study matched by sex and age with other dermatological patients to analyze possible risk factors associated with this disease. We included 15 cases and 45 controls, 67% were women. Bivariate and multivariate logistic regression analysis identified significant association with smoking, higher body mass index and family history. The use of hormonal contraceptives was less frequent in women with hidradenitis.
Authors:
Juliano Vilaverde Schmitt; Giovana Bombonatto; Manoela Martin; Hélio Amante Miot
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Type:  Journal Article    
Journal Detail:
Title:  Anais brasileiros de dermatologia     Volume:  87     ISSN:  1806-4841     ISO Abbreviation:  An Bras Dermatol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
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Nlm Unique ID:  0067662     Medline TA:  An Bras Dermatol     Country:  Brazil    
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Languages:  eng     Pagination:  936-8     Citation Subset:  IM    
Affiliation:
dermatology service, Hospital Universitário Evangélico de Curitiba, Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
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Journal Information
Journal ID (nlm-ta): An Bras Dermatol
Journal ID (iso-abbrev): An Bras Dermatol
Journal ID (publisher-id): An. bras. dermatol.
ISSN: 0365-0596
ISSN: 1806-4841
Publisher: Sociedade Brasileira de Dermatologia
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http://www.anaisdedermatologia.org.brhttp://www.scielo.br/abd©2012 by Anais Brasileiros de Dermatologia
open-access:
Received Day: 01 Month: 4 Year: 2012
Accepted Day: 15 Month: 5 Year: 2012
Print publication date: Season: Nov-Dec Year: 2012
Volume: 87 Issue: 6
First Page: 936 Last Page: 938
PubMed Id: 23197222
ID: 3699910
DOI: 10.1590/S0365-05962012000600024

Risk factors for hidradenitis suppurativa: a pilot study*
Juliano Vilaverde Schmitt1
Giovana Bombonatto2
Manoela Martin3
Hélio Amante Miot4
1Dermatologist - Preceptor of the dermatology service of the Hospital Universitário Evangélico de Curitiba - Faculdade Evangélica do Paraná (HUEC-FEPAR) - Curitiba (PR), Brazil
2Resident physician in internal medicine - Hospital Universitário Evangélico de Curitiba - Faculdade Evangélica do Paraná (HUEC-FEPAR) - Curitiba (PR), Brazil
3Trainee physician - Fundação Pró-Hansen (FPH) - Curitiba (PR), Brazil
4PhD Professor - PhD; assistant professor of the Dermatology and Radiotherapy Department of the Universidade Estadual Paulista "Julio de Mesquita Filho" (UNESP) - Botucatu (SP), Brazil
Correspondence: Mailing address: Juliano Vilaverde Schmitt, Av. Sete de Setembro, 4713, 80240-000 - Batel. Curitiba, PR, E-mail: julivs@gmail.com

The hidradenitis suppurativa (HS) is a chronic inflammatory disease, with a recurrent character and difficult to treat. It is believed to result firstly from the occlusion of the hair follicle, followed by secondary infection of the apocrine glands.1-5

Women are about four times more affected than men, and, since apocrine glands only begin their secretory activity in puberty, the disease usually begins after that period, mainly affecting areas rich in glands such as the axillary regions, inguinal, perineal, intergluteal, perianal and inframammary. 1-5

Although its etiology is not fully elucidated, some risk factors have been described in the literature, albeit controversial. We emphasize obesity, use of hormonal contraceptives (HC), smoking and diabetes. We found no Brazilian studies that have evaluated these risk factors in our population, much less in a multivariate analysis or controlled by dermatology patients.6

We conducted a case-control study matched by sex and age in the proportion of one case to three controls. We interviewed patients with hidradenitis suppurativa treated between 2008 and 2009 at a public clinic of dermatology, according to a standardized questionnaire. Controls were selected from patients attended in the same institution with others dermatologic problems at the same period. Data were compared in a bivariate and multivariate conditional logistic regression. We considered significant p values <0.05.

We included 15 cases and 45 controls, 67% were women. The current average age was 32.3 ± 11.6 years, with an age at onset of 20.6 ± 12.3 years. Nine patients had lesions in the armpits and 9 had lesions in the groin or genital area. One had inframammary lesions. Ten reported active disease in the last two months and 5 had undergone surgical drainage or excision.

Six patients reported a similar condition in first-degree relatives. Skin diseases more frequent in controls were dyschromia, acne, seborrheic dermatitis and leprosy.

In bivariate analysis, HS patients had higher smoking history, family history compatible with HS and higher BMI. Women with HS less frequently used HC (Table 1).

In multivariate analysis, we identified significant association with family history of HS, highest daily consumption of cigarettes and the interaction between body mass index (BMI) and age (Table 2). Among the cases there was a significant correlation between BMI and age at onset (Pearson R 2 = 0.65 / p <0.01).

Our data show age distribution, gender, and age at onset of the disease very similar to the literature. Likewise, the skin diseases present in the controls are compatible with the nosology of this age in our institution.4,5

The data reinforce the observations of other studies in terms of the association of HS with smoking and family history.7

Our data suggest a protective role of the use of HC. Similarly, recent work has verified the superiority of hormonal treatment when compared to other treatments such as antibiotics.8

Confirming previous studies, we identified elevated BMI as a risk factor for HS. However, in our data, BMI seemed to correlate with age at onset, suggesting that obesity should act as a risk factor especially among older patients. The association with obesity could be reflected in findings of insulin resistance, but the small sample size and the non performing of laboratory tests limited such observations.6

The family history of HS was a significant risk factor, as seen in several studies, some of which describe syndromic patterns with great genetic penetrance. However, we cannot rule out recall bias.9,10

Because this was a pilot study, this paper presents as the main limitation the small sample size. On the other hand, the pairing of the controls strengthens the results.

We conclude that the present study revealed risk factors previously reported in the literature regarding hidradenitis suppurativa, reinforcing the role of smoking, obesity and genetic susceptibility. The data suggest that regular use of HC could prevent the development or persistence of HS in women, but larger studies should be performed.


Notes

Conflict of interest: None

Financial funding: None

fn01* Work performed at the Dermatology Service of the Hospital Universitário Evangélico de Curitiba - Faculdade Evangélica do Paraná (HUEC-FEPAR) - Curitiba (PR), Brazil.

REFERENCES
1. Gee BC,Dawber RP. Hidradenitis suppurativaJ R Soc MedYear: 20009366111193069
2. Mortimer PS,Lunniss PJ. Hidradenitis suppurativaJ R Soc MedYear: 20009342042210983504
3. Obadia DL,Daxbacher EL,Jeunon T,Gripp AC. Hidradenite supurativa tratada com infliximabeAn Bras DermatolYear: 20098469569720191188
4. Rorison P,Ghosh M. Pathogenesis, clinical features and management of hidradenitis suppurativaAnn R Coll Surg EnglYear: 1997793859326135
5. Hughes LE. Pathogenesis, clinical features and management of hidradenitis suppurativaAnn R Coll Surg EnglYear: 1997793093109244085
6. Matusiak L,Bieniek A,Szepietowski JC. Hidradenitis suppurativa and associated factors: still unsolved problemsJ Am Acad DermatolYear: 20096136236519615551
7. Simonart T. Hidradenitis suppurativa and smokingJ Am Acad DermatolYear: 20106214915020082894
8. Kraft JN,Searles GE. Hidradenitippurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapyJ Cutan Med SurgYear: 20071112513117601419
9. Prasad PV,Kaviarasan PK,Joseph JM,Madhuri S,Viswanathan P. Familial acne inversa with acne conglobata in three generationsIndian J Dermatol Venereol LeprolYear: 20087428328518583816
10. Gao M,Wang PG,Cui Y,Yang S,Zhang YH,Lin D,et al. Inversa acne (hidradenitis suppurativa): a case report and identification of the locus at chromosome 1p21.11q25.3J Invest DermatolYear: 20061261302130616543891

Tables
[TableWrap ID: t01] Table 1 

Bivariate analysis of characteristics, according to the groups with (cases) and without (controls) hidradenitis suppurativa (N = 60)


Variables All (N=60) Cases (N=15) Controls (N=45) Odds Ratio (confidence interval 95%) p
Current age (years)* 31,7±11,3 32,3±12,0 31,4±11,3   0,78
Females** 40 (67%) - - - -
Weight (Kg)* 68,5±14,6 72,3±19,1 67,2±13,0 - 0,52
Body mass index* 24,7±4,6 26,9±5,9 24,0±4,0 - <0,05
Hormonal contraceptives - women** 11 (31%) 0 (0%) 12 (40%) - 0,02
Family history of hidradenitis suppurativa ** 9 (15%) 6 (40%) 3 (7%) 9,33 (1,96 to 44,49) <0,01
Smoking history** 23 (38%) 9 (60%) 14 (31%) 3,32 (1,00 to 11,14) <0,05
Smoking (cigarettes per day)*** 0±11,25 9±20 0±5 - <0,05

t01-fn01* Student's T test, mean ± standard deviation; ** Fisher's exact test; *** Mann-Withney test, median ± interquartile range.


[TableWrap ID: t02] Table 2 

Multivariate conditional logistic regression of the controlled variables selected according to a "backward stepwise" algorithm (N = 60)


Variables Odds Ratio (confidence interval 95%) p
     
Females - paired 1.06 (0.19 to 5.92) 0.95
Current age - paired 0.62 (0.41 to 0.96) 0.03
Family history of hidradenitis suppurativa 20.43 (2.38 to 175.7) <0.01
Smoking (cigarettes per day) 1.14 (1.02 to 1.28) 0.02
Body mass index 0.75 (0.46 to 1.22) 0.24
Body mass index versus age 1.02 (1.00 to 1.03) <0.05
Constant - 0.25

t02-fn01Dependent variable: To present hidradenitis suppurativa; model p <0.01, correct classification = 85%.



Article Categories:
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Keywords: Hidradenitis suppurativa, Obesity, Risk factors, Smoking.

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