Document Detail


Risk factors for heart failure: a population-based case-control study.
MedLine Citation:
PMID:  19854330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The relative contribution of risk factors to the development of heart failure remains controversial. Further, whether these contributions have changed over time or differ by sex is unclear. Few population-based studies have been performed. We aimed to estimate the population attributable risk (PAR) associated with key risk factors for heart failure in the community.
METHODS: Between 1979 and 2002, 962 incident heart failure cases in Olmsted County were age and sex-matched to population-based controls using Rochester Epidemiology Project resources. We determined the frequency of risk factors (coronary heart disease, hypertension, diabetes mellitus, obesity, and smoking), odds ratios, and PAR of each risk factor for heart failure.
RESULTS: The mean number of risk factors for heart failure per case was 1.9 + or - 1.1 and increased over time (P<.001). Hypertension was the most common (66%), followed by smoking (51%). The prevalence of hypertension, obesity, and smoking increased over time. The risk of heart failure was particularly high for coronary disease and diabetes with odds ratios (95% confidence intervals) of 3.05 (2.36-3.95) and 2.65 (1.98-3.54), respectively. However, the PAR was highest for coronary disease and hypertension; each accounted for 20% of heart failure cases in the population, although coronary disease accounted for the greatest proportion of cases in men (PAR 23%) and hypertension was of greatest importance in women (PAR 28%).
CONCLUSION: Preventing coronary disease and hypertension will have the greatest population impact in preventing heart failure. Sex-targeted prevention strategies might confer additional benefit. However, these relationships can change, underscoring the importance of continued surveillance of heart failure.
Authors:
Shannon M Dunlay; Susan A Weston; Steven J Jacobsen; Véronique L Roger
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  122     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2009-11-10     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1023-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Coronary Disease / complications,  epidemiology
Female
Heart Failure / epidemiology*,  etiology
Humans
Hypertension / complications,  epidemiology
Incidence
Male
Obesity / complications,  epidemiology
Odds Ratio
Population Surveillance*
Prevalence
Retrospective Studies
Risk Assessment / methods*
Risk Factors
Sex Distribution
Smoking / adverse effects,  epidemiology
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HL72435/HL/NHLBI NIH HHS; R01 AR030582/AR/NIAMS NIH HHS; R01 HL072435/HL/NHLBI NIH HHS; R01 HL072435-07/HL/NHLBI NIH HHS; R01-AR30582/AR/NIAMS NIH HHS; T32 HL007111/HL/NHLBI NIH HHS; T32 HL007111-31A1/HL/NHLBI NIH HHS; T32 HL07111-31A1/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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