| Risk factors and growth factors in ROP. | |
| | |
MedLine Citation:
|
PMID: 19828269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Retinopathy of prematurity (ROP) is a multifactorial disease which incidence is increasing with increasing survival of very preterm infants. Pathogenic pathway is characterised by abnormal retinal vascular development modulated by vascular growth factors: low IGF-1 in the first phase and high VEGF in the second phase. Many causal factors are able to influence retinal vascularization: gestational age, birth weight, oxygen administration, perinatal bacterial or fungal infections, and blood transfusions. All risk factors, both oxygen and not-oxygen-regulated, have been studied considering the whole period from hospital birth to the hospital discharge, but it is possible that postnatal risk factors may be determinant in a time-dependent way. Analysis of factors involved in the pathogenesis of ROP suggests that their action begins long before anatomical clinical features become appreciable and this is strengthened by the essential role of risk factors from the first two to four weeks of life, thus preventive strategies in very preterm infants should be carried out since birth. |
| | |
Authors:
|
C Romagnoli |
Related Documents
:
|
6885629 - A quantitative study of cat epiglottal taste buds during development. 16366189 - Retinopathy of prematurity. 1377269 - Cryotherapy for retinopathy of prematurity in a regional neonatal intensive care unit. 20845249 - [vegf antibodies as therapy for retinopathy of prematurity]. 20640099 - Capnography guided awake nasal intubation in a 4 month infant with pierre robin syndrom... 3983249 - The superficial musculoaponeurotic system in the upper lip: an anatomic study in cadavers. 15479659 - Teenage mothers and breastfeeding: does paternal age make a difference? 7369719 - Familial stroke syndrome associated with mitral valve prolapse. 8132869 - Morphology of developing rat genioglossal motoneurons studied in vitro: changes in leng... |
Publication Detail:
|
Type: Journal Article Date: 2009-10-14 |
Journal Detail:
|
Title: Early human development Volume: 85 ISSN: 1872-6232 ISO Abbreviation: Early Hum. Dev. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-11-02 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
|
Languages: eng Pagination: S79-82 Citation Subset: IM |
Affiliation:
|
Division of Neonatology, Catholic University of Rome, Largo A. Gemelli, 8 00168, Rome, Italy. j.rampazzi@emec-roma.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Birth Weight Blood Transfusion / adverse effects Gestational Age Humans Infant, Newborn Insulin-Like Growth Factor I / metabolism Oxygen / adverse effects, therapeutic use Retinopathy of Prematurity / epidemiology*, pathology, prevention & control Risk Factors Time Factors Vascular Endothelial Growth Factor A / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 67763-96-6/Insulin-Like Growth Factor I; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biology and intracellular pathogenesis of high or low virulent Chlamydophila psittaci strains in chi...
Next Document: Comparison of the strengths and difficulties questionnaire (SDQ) scores between children with high-f...