Document Detail

Risk factors and growth factors in ROP.
MedLine Citation:
PMID:  19828269     Owner:  NLM     Status:  MEDLINE    
Retinopathy of prematurity (ROP) is a multifactorial disease which incidence is increasing with increasing survival of very preterm infants. Pathogenic pathway is characterised by abnormal retinal vascular development modulated by vascular growth factors: low IGF-1 in the first phase and high VEGF in the second phase. Many causal factors are able to influence retinal vascularization: gestational age, birth weight, oxygen administration, perinatal bacterial or fungal infections, and blood transfusions. All risk factors, both oxygen and not-oxygen-regulated, have been studied considering the whole period from hospital birth to the hospital discharge, but it is possible that postnatal risk factors may be determinant in a time-dependent way. Analysis of factors involved in the pathogenesis of ROP suggests that their action begins long before anatomical clinical features become appreciable and this is strengthened by the essential role of risk factors from the first two to four weeks of life, thus preventive strategies in very preterm infants should be carried out since birth.
C Romagnoli
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Publication Detail:
Type:  Journal Article     Date:  2009-10-14
Journal Detail:
Title:  Early human development     Volume:  85     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S79-82     Citation Subset:  IM    
Division of Neonatology, Catholic University of Rome, Largo A. Gemelli, 8 00168, Rome, Italy.
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MeSH Terms
Birth Weight
Blood Transfusion / adverse effects
Gestational Age
Infant, Newborn
Insulin-Like Growth Factor I / metabolism
Oxygen / adverse effects,  therapeutic use
Retinopathy of Prematurity / epidemiology*,  pathology,  prevention & control
Risk Factors
Time Factors
Vascular Endothelial Growth Factor A / metabolism
Reg. No./Substance:
0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 67763-96-6/Insulin-Like Growth Factor I; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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