| Risk factors for fatal myocardial infarction after coronary bypass graft surgery. | |
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MedLine Citation:
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PMID: 11350475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: The incidence and clinical impact of perioperative myocardial infarction during coronary artery bypass graft surgery vary greatly depending upon the diagnostic criteria applied. Fatal perioperative myocardial infarction has a less arguable diagnosis and clinical impact. The aim of this paper is to find out the risk factors for fatal myocardial infarction after coronary surgery. METHODS: Data from 1561 consecutive patients, who underwent coronary revascularization during a 10-month period, have been retrospectively analysed. After an univariate analysis for pre- and intraoperative risk factors, a multivariate model (logistic regression analysis) was settled. RESULTS: Preoperative use of subcutaneous/intravenous heparin, a heparin sensitivity index < 1.3 and need for a thromboendarterectomy of the left anterior descending coronary artery are independent risk factors for fatal myocardial infarction. The relative risk for fatal myocardial infarction was about 2 in the case of preoperative heparin use or heparin sensitivity index < 1.3 and 5.5 in the case of thromboendarterectomy of the left anterior descending coronary artery. CONCLUSIONS: In patients undergoing coronary artery bypass surgery, preoperative anticoagulation management with heparin may represent a risk factor for fatal myocardial infarction. Patterns of heparin resistance, whether or not due to heparin pretreatment, seem to be closely related to fatal myocardial infarction. |
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Authors:
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M Ranucci; A Frigiola; L Menicanti; A Cazzaniga; G Soro; G Isgrò |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 18 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-14 Completed Date: 2001-07-05 Revised Date: 2011-01-11 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 322-9 Citation Subset: IM |
Affiliation:
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Departments of Cardiovascular Anesthesia and Cardiac Surgery, Cardiovascular Center E. Malan, University of Milan, San Donato Hospital, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Bypass / mortality* Endpoint Determination Female Humans Logistic Models Male Middle Aged Multivariate Analysis Myocardial Infarction / mortality* Postoperative Complications / mortality* Retrospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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