Document Detail

Risk factors for early sepsis in very low birth weight neonates with respiratory distress syndrome.
MedLine Citation:
PMID:  18052996     Owner:  NLM     Status:  MEDLINE    
AIM: To identify maternal and neonatal factors that increase suspicion of early sepsis in Very Low Birth Weight neonates with respiratory distress syndrome. METHODS: The cohort included 282 neonates born at Soroka Medical Centre 1996-2000. Definitions of 'high' and 'low'-suspicion groups for early sepsis were based on comparison between neonates with early sepsis and the remaining cohort. Univariate analysis and logistic regression were used to compare between groups. RESULTS: The incidence of early sepsis in the cohort was 1.8%, and 94% received antibiotics following delivery. Comparing with the remaining cohort, the five neonates with early sepsis had increased incidence of positive maternal cultures, use of antenatal antibiotics, lower 1 min Apgar scores and tendency to leucopenia. A 'low-suspicion' group comprised 38% of the cohort and did not include any neonates with early sepsis. This group were more frequently treated with antenatal steroids and delivered by Caesarean section compared to the 'high-suspicion' group, but otherwise there were no clinical and laboratory differences. CONCLUSION: Although the incidence of early sepsis is low almost all neonates received antibiotics. A 'low-suspicion' group was defined and the role of antibiotic treatment in this group needs to be determined.
Laliv Shani; Dahlia Weitzman; Rimma Melamed; Ehud Zmora; Kyla Marks
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-12-03
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  12-5     Citation Subset:  IM    
Faculty of Health Science, Ben Gurion University, Beer Sheva, Israel.
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MeSH Terms
Cohort Studies
Infant, Newborn
Infant, Very Low Birth Weight
Respiratory Distress Syndrome, Newborn / complications*
Risk Factors
Sepsis / complications*,  epidemiology*

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