Document Detail

Risk factors for the development of gastric mucosal lesions in rheumatoid arthritis patients receiving long-term nonsteroidal anti-inflammatory drug therapy and the efficacy of famotidine obtained from the FORCE study.
MedLine Citation:
PMID:  19728013     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to investigate the prevalence of gastric mucosal injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatoid arthritis (RA). Upper gastrointestinal endoscopy was performed on 100 RA patients treated with NSAIDs. Patient factors potentially contributing to the development of NSAID-induced gastric mucosal injury were identified by logistic regression analysis; gastric mucosal injury and ulcers were used as objective variables. Gastric mucosal injury was detected in 62 of 100 patients, and eight of these patients had ulcers. Previous history of ulcers, lifestyle, NSAID dosage, and body mass index were associated with the development of gastric mucosal injury,and the use of diclofenac and steroid dose were associated with the development of ulcers. Disease-modifying antirheumatic drugs (DMARDs) did not appear to influence the risk of NSAID-induced gastric mucosal injury. RA patients treated for long periods with NSAIDs for RA symptoms should be controlled with DMARDs, without consideration of increased doses of steroids, in terms of risk for NSAID-induced gastric mucosal injury. Simultaneously, concomitant use of histamine-2 receptor antagonists (H2RA) such as famotidine should be considered.
Yasunori Kobata; Hiroshi Yajima; Junichi Yamao; Yasuhito Tanaka; Hiroshi Fukui; Yoshinori Takakura
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  19     ISSN:  1439-7609     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-10     Completed Date:  2010-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  629-36     Citation Subset:  IM    
Department of Orthopaedic Surgery, Nara Medical University,840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Anti-Ulcer Agents / therapeutic use
Arthritis, Rheumatoid / drug therapy*
Famotidine / therapeutic use*
Gastric Mucosa / injuries*,  pathology
Middle Aged
Regression Analysis
Risk Factors
Severity of Illness Index
Stomach Diseases / chemically induced*,  pathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anti-Ulcer Agents; 76824-35-6/Famotidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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