Document Detail

Risk factors for complete molar pregnancy from a case-control study.
MedLine Citation:
PMID:  4025447     Owner:  NLM     Status:  MEDLINE    
Demographic, reproductive, and dietary histories for 90 white women with complete molar pregnancy were compared in a multivariate analysis with those of 90 parous controls matched to cases by residence, birth year, and race. Women with molar pregnancy were more likely to have been born outside North America (relative risk = 1.9, p = 0.05), were more likely to have been past age 30 at time of their molar pregnancy (relative risk = 1.6, p = 0.05), and were more likely to have diets deficient in the vitamin A precursor carotene. Women with dietary scores for carotene above the control median had a relative risk for molar pregnancy of 0.6 (p = 0.02). In addition, there was a significant trend for decreasing risk for molar pregnancy with increasing consumption of carotene. Although other nutritional deficiencies in patients with complete molar pregnancy may exist, carotene is a biologically plausible candidate for a nutritional risk factor that could explain the geographic distribution of molar pregnancy.
R S Berkowitz; D W Cramer; M R Bernstein; S Cassells; S G Driscoll; D P Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  152     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-24     Completed Date:  1985-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1016-20     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Carotenoids / metabolism
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Food Habits
Hydatidiform Mole / epidemiology*,  etiology
Uterine Neoplasms / epidemiology*,  etiology
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Proteins; 36-88-4/Carotenoids

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