Document Detail

Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure.
MedLine Citation:
PMID:  19699873     Owner:  NLM     Status:  In-Process    
BACKGROUND: Over 25% of patients with congenital heart disease are obese (OB) or overweight (OW). Unique factors such as activity restriction and early feeding practices may play a role. We evaluated a high-risk cohort predisposed to early coronary artery disease due to past surgery involving coronary artery reimplantation. METHODS: Patients at our institution who underwent the arterial switch or Ross operation were included. Data collection included chart review and activity and diet questionnaires. The proportion of OB/OW (body mass index > or =85%) was compared to national data. Factors associated with OB/OW were evaluated. RESULTS: A total of 106 patients were enrolled. Median age was 14.2 years (6.0-19.9 years); 69% were male. Similar to national data, 31% were OB/OW (vs 31%, P = nonsignificant [NS]). There was no difference comparing OB/OW to normal-weight patients in activity restriction (cardiologist documented 27% vs 27%; parent reported 38% vs 42%, P = NS), activity level (9.8 hours/week [1.7-41.2] vs 11.5 [0.8-52.3], P = NS), or early feeding practices (formula vs breastfeeding, caloric fortification, tube feeding). OB/OW patients were more likely to have an OB parent (70% vs 37%, P = .01). Left ventricular mass index was higher in OB/OW patients (48.8 g/m(2.7) [24.4-120.6] vs 37.7 g/m(2.7) [16.5-85.1], P = .01). CONCLUSIONS: Nearly one third of ASO and Ross patients were OB/OW. Obese/overweight was not found to be related to activity restriction or early feeding practices, but was associated with parental obesity. Obese or OW patients had higher left ventricular mass. Obesity and associated comorbidities may pose additional cardiovascular risk in this unique population who underwent coronary artery reimplantation in childhood.
Sara K Pasquali; Bradley S Marino; Anita Pudusseri; Gil Wernovsky; Stephen M Paridon; Susan A Walker; Meryl S Cohen
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Publication Detail:
Type:  Journal Article     Date:  2009-07-23
Journal Detail:
Title:  American heart journal     Volume:  158     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-9     Citation Subset:  AIM; IM    
The Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
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