Document Detail

Risk factors for coarctation of the aorta.
MedLine Citation:
PMID:  8367829     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that environmental factors during early pregnancy may cause coarctation of the aorta (CoA), 50 cases of CoA and 756 controls were studied. The cases represented all verified CoAs in Finland during 1982-1983 and controls were randomly selected from all babies born during the same period. Both case and control mothers were interviewed by midwives approximately 3 months after delivery. In these data 18 patients had pure CoA only and the remaining 32 at least one other cardiac anomaly. Three CoA patients had a chromosomal anomaly. The relatives of CoA babies had more congenital anomalies than those of the control babies. Maternal overall exposure to chemicals at work was slightly more prevalent among the CoA group (32.0%) than the control group (26.2%). Maternal exposure to mineral oil products at work during early pregnancy was more common among CoA cases (8.0%) than controls (1.4%) [odds ratio (OR) = 5.9, 95% confidence interval (CI95) = 1.8-19.2]. The risk of CoA was also associated with previous miscarriages (OR = 2.3, CI95 = 1.2-4.4) and twin birth (OR = 16.3, CI95 = 4.0-67) of the child. The risk of CoA was not associated with seasonal variation, maternal smoking, alcohol consumption, or use of deodorants. It is concluded that genetic factors explain only a small fraction of the causes of CoA and that many common environmental exposures during early pregnancy are unlikely to be real risk factors for CoA. However, the power of this study was weak for testing the teratogenicity of specific chemicals.
J Tikkanen; O P Heinonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Teratology     Volume:  47     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-04     Completed Date:  1993-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-72     Citation Subset:  IM    
National Public Health Institute, Helsinki, Finland.
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MeSH Terms
Aortic Coarctation / epidemiology*,  etiology
Case-Control Studies
Finland / epidemiology
Infant, Newborn
Occupational Exposure
Risk Factors
Reg. No./Substance:
Comment In:
Teratology. 1993 Nov;48(5):397   [PMID:  8303609 ]

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