Document Detail


Risk factors and clinicopathological study of prognostic factors in the peritoneal mesothelioma.
MedLine Citation:
PMID:  20420251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluates the clinical and treatment related prognostic indicators for survival of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma. We did an observational study of the risk factors and clinicopathological factors of 20 patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma at the St George Hospital, Sydney. Survival analysis was performed using the Kaplan-Meier method and prognostic factors were correlated with survival using the Log Rank test. There were six females. The mean age was 55 years. The overall median survival was 30 (0.5-87) months with 1- and 3-year survival of 78 per cent and 46 per cent, respectively. The overall median disease-free survival was 8 months. Factors influencing a longer disease-free survival included age > or = 55 (P = 0.006), not smoking (P = 0.04), female (P = 0.03), and epithelioid tumors (P = 0.002). Overall survival was influenced by not consuming alcohol (P = 0.003), complete cytoreduction (P = 0.02), and epithelioid tumors (P = 0.01). Risk factors identified to be prognostic for survival include the female gender, not smoking, not consuming alcohol, and an epithelioid tumor type. Treatment factor associated with an improved survival was a complete cytoreduction.
Authors:
Edward C G Tudor; Terence C Chua; Winston Liauw; David L Morris
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  76     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  400-5     Citation Subset:  IM    
Affiliation:
University of New South Wales, Department of Surgery, St George Hospital, Kogarah, Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Combined Modality Therapy
Female
Humans
Hyperthermia, Induced*
Male
Mesothelioma / drug therapy*,  pathology,  surgery*
Middle Aged
Neoplasm Recurrence, Local
Peritoneal Neoplasms / drug therapy*,  pathology,  surgery*
Prognosis
Risk Factors
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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