Document Detail

Risk factors for clinical anastomotic leakage following the resection of sigmoid and rectal cancer.
MedLine Citation:
PMID:  16227705     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to determine the risk factors for the leakage after sigmoid and rectal cancer resections depending on the height of anastomoses. MATERIAL AND METHODS: Data of 269 patients, who underwent primary resection of colorectal cancer, were analyzed retrospectively: 21 patients underwent proctectomy with Parks coloanal anastomosis, 78--low anterior resection of rectum, 67--high anterior resection of rectum and 103--resection of sigmoid colon with colorectal anastomosis. Preoperative radiotherapy was performed on 61 patients. RESULTS: Anastomotic leakage occurred in 20 (7.4%) patients. Multivariate analysis of the overall population showed that the risk of anastomotic leakage was 3.9 times higher for males (p=0.02) and 3.5 times higher for anastomoses situated at or below 10 cm from the anal verge (p=0.01). Multivariate analysis of low colorectal and coloanal anastomoses (n=99) showed that only male sex was an independent factor. Multivariate analysis of patients with anastomosis situated higher than 10 cm from the anal verge (n=170) showed that the preoperative condition of the patient was as independent factor for the development of anastomotic leakage. CONCLUSIONS: Low rectal anastomoses are at risk for anastomotic leakage, especially in males and in generally unfit patients.
Giedre Rudinskaite; Algimantas Tamelis; Zilvinas Saladzinskas; Dainius Pavalkis
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Medicina (Kaunas, Lithuania)     Volume:  41     ISSN:  1648-9144     ISO Abbreviation:  Medicina (Kaunas)     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9425208     Medline TA:  Medicina (Kaunas)     Country:  Lithuania    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Department of Surgery, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania.
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MeSH Terms
Age Factors
Aged, 80 and over
Anastomosis, Surgical / adverse effects*
Colon / pathology,  surgery*
Colon, Sigmoid / pathology,  surgery
Colorectal Neoplasms / pathology,  radiotherapy,  surgery*
Combined Modality Therapy
Data Interpretation, Statistical
Middle Aged
Multivariate Analysis
Neoplasm Staging
Postoperative Complications
Preoperative Care
Radiotherapy Dosage
Rectum / pathology,  surgery*
Retrospective Studies
Risk Factors
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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