Document Detail

Risk factors for cardiovascular disease in children and young adults after renal transplantation.
MedLine Citation:
PMID:  17699360     Owner:  NLM     Status:  MEDLINE    
Despite good outcomes in pediatric renal transplantation, life expectancy is reduced, mostly as a result of accelerated atherosclerosis. A comprehensive evaluation of cardiac status and risk factors for cardiovascular disease was performed in 60 patients after renal transplantation (age 3 to 29 yr; mean 15.8). Posttransplantation diabetes was diagnosed in 7%. Half of the patients did not engage in any physical activity, and this was associated with increased body mass index. Uncontrolled hypertension was found in 13% of patient, and 53% were on antihypertensive medications. BP index was associated with left ventricular mass index (LVMI). Dyslipidemia was relatively uncommon, with hypercholesterolemia found in 15% and elevated LDL cholesterol found in 10% of patients. Hyperhomocysteinemia was frequent (58%); in most patients, it was not due to folate or B(12) deficiency. Lipid and homocysteine abnormalities were associated with cyclosporine therapy. Echocardiography demonstrated normal LVMI in 93% of patients, although LVMI was higher than in healthy control subjects. Cardiac troponin I was normal in all patients, but N-terminal pro-brain natriuretic peptide was elevated in 35% and was associated with LVMI and renal function. Although present cardiac status is relatively normal in pediatric renal transplantation patients, cardiac risk factors are common, and strategies to prevent cardiovascular disease need to be developed.
Rachel Becker-Cohen; Amiram Nir; Choni Rinat; Sofia Feinstein; Nurit Algur; Benjamin Farber; Yaacov Frishberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-20
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  1     ISSN:  1555-905X     ISO Abbreviation:  -     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1284-92     Citation Subset:  IM    
Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Body Mass Index
Cardiovascular Diseases / epidemiology*
Coronary Disease / genetics
Hypertension / epidemiology
Immunosuppressive Agents / adverse effects,  therapeutic use
Kidney Diseases / classification,  surgery
Kidney Transplantation / adverse effects*,  immunology
Patient Selection
Risk Factors
Smoking / adverse effects
Treatment Outcome
Reg. No./Substance:
0/Immunosuppressive Agents

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