| Risk factors for cardiovascular disease in children and young adults after renal transplantation. | |
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MedLine Citation:
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PMID: 17699360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite good outcomes in pediatric renal transplantation, life expectancy is reduced, mostly as a result of accelerated atherosclerosis. A comprehensive evaluation of cardiac status and risk factors for cardiovascular disease was performed in 60 patients after renal transplantation (age 3 to 29 yr; mean 15.8). Posttransplantation diabetes was diagnosed in 7%. Half of the patients did not engage in any physical activity, and this was associated with increased body mass index. Uncontrolled hypertension was found in 13% of patient, and 53% were on antihypertensive medications. BP index was associated with left ventricular mass index (LVMI). Dyslipidemia was relatively uncommon, with hypercholesterolemia found in 15% and elevated LDL cholesterol found in 10% of patients. Hyperhomocysteinemia was frequent (58%); in most patients, it was not due to folate or B(12) deficiency. Lipid and homocysteine abnormalities were associated with cyclosporine therapy. Echocardiography demonstrated normal LVMI in 93% of patients, although LVMI was higher than in healthy control subjects. Cardiac troponin I was normal in all patients, but N-terminal pro-brain natriuretic peptide was elevated in 35% and was associated with LVMI and renal function. Although present cardiac status is relatively normal in pediatric renal transplantation patients, cardiac risk factors are common, and strategies to prevent cardiovascular disease need to be developed. |
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Authors:
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Rachel Becker-Cohen; Amiram Nir; Choni Rinat; Sofia Feinstein; Nurit Algur; Benjamin Farber; Yaacov Frishberg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-20 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 1 ISSN: 1555-905X ISO Abbreviation: - Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1284-92 Citation Subset: IM |
Affiliation:
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Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel. rbeckercohen@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Mass Index Cardiovascular Diseases / epidemiology* Child Coronary Disease / genetics Female Humans Hypertension / epidemiology Immunosuppressive Agents / adverse effects, therapeutic use Kidney Diseases / classification, surgery Kidney Transplantation / adverse effects*, immunology Male Patient Selection Pregnancy Risk Factors Smoking / adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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