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Risk factors for asymptomatic ventricular dysfunction in rheumatoid arthritis patients.
MedLine Citation:
PMID:  24368945     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Objective. The aim of the study was to describe echocardiographic abnormalities in patients with rheumatoid arthritis, concurrent systemic comorbidities, rheumatologic clinical activity, serologic markers of rheumatoid arthritis, and inflammatory activity. Methods. In an observational, cross-sectional study, rheumatoid arthritis outpatients were included (n = 105). Conventional transthoracic echocardiographic variables were compared between patients with arthritis and non-RA controls (n = 41). For rheumatoid arthritis patients, articular activity and rheumatologic and inflammatory markers were obtained. Results. Ventricular dysfunction was found in 54.3% of the population: systolic (18.1%), diastolic (32.4%), and/or right (24.8%), with lower ejection fraction (P < 0.0001). Pulmonary hypertension was found in 46.9%. Other echocardiographic findings included increased left atrial diameter (P = 0.01), aortic diameter (P = 0.01), ventricular septum (P = 0.01), left ventricular posterior wall (P = 0.013), and right ventricular (P = 0.01) and atrial diameters compared to control subjects. Rheumatoid factor and anti-CCP antibodies levels were significantly elevated in cases with ventricular dysfunction. Angina and myocardial infarction, diabetes, and dyslipidemia were the main risk factors for ventricular dysfunction. Conclusions. Ventricular dysfunction is common in rheumatoid arthritis and associated with longer disease duration and increased serologic markers of rheumatoid arthritis. Screening for cardiac abnormalities should be considered in this kind of patients.
Authors:
Carlos Garza-García; Sánchez-Santillán Rocío; Arturo Orea-Tejeda; Lilia Castillo-Martínez; Canseco Eduardo; José Luis López-Campos; Candace Keirns-Davis
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Publication Detail:
Type:  Journal Article     Date:  2013-12-03
Journal Detail:
Title:  ISRN cardiology     Volume:  2013     ISSN:  2090-5580     ISO Abbreviation:  ISRN Cardiol     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-25     Completed Date:  2013-12-25     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101566293     Medline TA:  ISRN Cardiol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  635439     Citation Subset:  -    
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