Document Detail

Risk factors associated with the severity of thyroid-associated orbitopathy in Korean patients.
MedLine Citation:
PMID:  21052505     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study is to identify risk factors for severe thyroid-associated orbitopathy (TAO) and compressive optic neuropathy in Korean patients.
METHODS: This study was a retrospective comparative case series. All TAO patients who were first seen at our institution between 2005 and 2009 and who had follow-up periods of at least 6 months were included. Patients were divided into mild or moderate and severe TAO groups. Cases were also segregated based on the presence or absence of optic neuropathy. Demographics, smoking status, comorbidities, thyroid hormonal status, thyroid autoantibody levels, and clinical presentations were assessed.
RESULTS: A total of 99 patients (83 with mild to moderate courses and 16 with severe courses; 90 without optic neuropathy and 9 with optic neuropathy) were included in this study. On multiple logistic regression analysis, smoking status was a predictive risk factor for a severe course of TAO and the development of optic neuropathy (odds ratios = 6.57 and 10.00, respectively). Other factors such as age, gender, free T4 level, thyroid binding-inhibiting immunoglobulin, and a history of diabetes were not predictive of severe TAO or optic neuropathy.
CONCLUSIONS: Although various factors may influence the severity of TAO and the development of optic neuropathy, this study showed that smoking was a risk factor for severe TAO and the development of optic neuropathy. Therefore, it is important for patients with Graves' disease to refrain from smoking. Frequent and careful observation should also be performed in current smokers, as TAO patients who smoke are susceptible to a severe course and/or optic neuropathy.
Ji Hwan Lee; Sang Yeul Lee; Jin Sook Yoon
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-10-05
Journal Detail:
Title:  Korean journal of ophthalmology : KJO     Volume:  24     ISSN:  1011-8942     ISO Abbreviation:  Korean J Ophthalmol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-03-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8804513     Medline TA:  Korean J Ophthalmol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Chi-Square Distribution
Graves Ophthalmopathy / epidemiology,  etiology*
Logistic Models
Middle Aged
Republic of Korea / epidemiology
Retrospective Studies
Risk Factors
Severity of Illness Index
Smoking / adverse effects*,  epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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