| Risk factors associated with high hemoglobin A1C levels (≥5.7%) in Korean adults with normal fasting glucose. | |
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MedLine Citation:
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PMID: 21970859 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Early detection of high risk for type 2 diabetes (T2DM) and early diagnosis of T2DM are fundamental for the prevention of diabetes and associated complications. Aim: To identify the major predictors of high hemoglobin A1C (HbA1C) levels in people with normal fasting glucose levels. Subjects and Methods: This was a cross-sectional study involving 8,035 adults aged 20 years and over. Multivariate logistic regression analyses were done to estimate the odd ratios (ORs) of clinical risk factors for high HbA1C (≥5.7%) in the subjects with normal fasting glucose levels (<100 mg/dL). Results: Except for fasting glucose levels, age and total cholesterol levels were significantly associated with HbA1C levels. After adjustment for gender, fasting glucose, and behavioral factors, OR for high HbA1C levels for age (≥40 year olds) and high total cholesterol levels (≥200 mg/dL) were 2.27 (95% CI: 2.01-2.56) and 1.76 (95% CI: 1.56-1.97), respectively. Each OR was higher than that of metabolic syndrome (MS) (OR=1.59, 95% CI: 1.34-1.87). Coexistence of both factors had a higher OR (OR=2.40, 95% CI: 2.11-2.72) for high HbA1C levels when compared to each factor alone. Conclusions: HbA1C was significantly associated with fasting glucose, age, and total cholesterol levels. In subjects with normal fasting glucose levels, age of over 40 years or high total cholesterol levels (≥ 200 mg/dL) is more predictive of high HbA1C levels than MS. These findings suggest that both factors might be better predictors than MS for the screening of prediabetes or diabetes in clinical practice. |
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Authors:
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S Y Choi; K E Yun; H J Choi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-3 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Family Medicine, Eulji University Hospital, Daejeon, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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