Document Detail

Risk factors associated with chronic lung disease in Malaysian very low birthweight infants.
MedLine Citation:
PMID:  17682569     Owner:  NLM     Status:  MEDLINE    
To determine the significant risk factors associated with development of chronic lung disease (CLD) in Malaysian very low birthweight (VLBW, < 1501g) infants. A prospective observational study was carried out at the Sarawak General Hospital (SGH) in Kuching, over a period of 29 months from 1 April 2003 to 31 August 2005. Infants with birthweight between 600g to 1500g admitted to this hospital were recruited. The progress of these infants was followed till discharge. CLD was defined as the persistent need for oxygen therapy to maintain oxygen saturation above 88% at 36 weeks of postmenstrual age. Of the 224 infants recruited, 36 (14.8%) had CLD. Logistic regression analysis showed that lower birth weight (adjusted odds ratio (OR) = 0.996, 95% confidence intervals (CI) = 0.994, 0.998; p = 0.001), male infants (adjusted OR = 3.9, 95% CI = 1.6, 11.7; p = 0.02), chorioamnionitis (adjusted OR = 9.0, 95% CI = 1.6, 50.8; p = 0.01), severe respiratory distress syndrome of grades 3 or 4 (adjusted OR = 4.6, 95% CI =1.6, 13.2; P = 0.005) and patent ductus arteriosus (adjusted OR = 4.3, 95% CI = 1.5, 12.8; p = 0.007) were significant risk factors associated with development of CLD. A number of treatable conditions are associated with development of CLD in Malaysian VLBW infants.
S A K M Ameenudeen; N Y Boo; L G Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Medical journal of Malaysia     Volume:  62     ISSN:  0300-5283     ISO Abbreviation:  Med. J. Malaysia     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361547     Medline TA:  Med J Malaysia     Country:  Malaysia    
Other Details:
Languages:  eng     Pagination:  40-5     Citation Subset:  IM    
Department of Paediatrics, Sarawak General Hospital, Kuching, Sarawak.
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MeSH Terms
Infant, Newborn
Infant, Very Low Birth Weight* / physiology
Lung Diseases / etiology*,  physiopathology
Prospective Studies
Risk Factors

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