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Risk factors associated with altered fetal growth in patients with pregestational diabetes mellitus.
MedLine Citation:
PMID:  22070854     Owner:  NLM     Status:  Publisher    
Abstract Objective To assess the risk factors for abnormal fetal growth in patients with pregestational diabetic mellitus (DM). Methods A retrospective study was performed in 336 patients with pregestational DM. Small-for-gestational-age (SGA) and large-for-gestational-age (LGA) infants were defined as newborns with birth weights < 10(th) percentile and > 90(th) percentile, respectively. Logistic regression analysis was performed to identify risk factors for SGA and LGA. Results Multivariate analysis of the patients with pregestational DM revealed a significant difference between patients who delivered SGA and appropriate-for-gestational-age (AGA) infants in terms of retinopathy (OR?=?5.73, 95%CI?=?1.39?23.59) and hemoglobin A1C (HbA1C) before delivery (OR?=?0.80, 95%CI?=?0.68 ? 0.94, with a 0.1% increase in DCCT unit). Multivariate analysis revealed a significant difference between patients who delivered LGA and AGA infants in terms of primipara (OR?=?3.40, 95%CI?=?1.47?7.87) and HbA1C before delivery (OR?=?1.14, 95%CI?=?1.07?1.21, with a 0.1% increase in DCCT unit). Conclusions HbA1C before delivery influenced both SGA and LGA infants in patients with pregestational DM. Tight glycemic control might be harmful to fetal growth in pregestational diabetic patients, especially when complicated with retinopathy.
Eriko Kanda; Yoshio Matsuda; Mayumi Sanaka; Yasuo Makino; Hideo Matsui
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-10
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Tokyo Women?s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan and.
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