Document Detail

Risk factors and associated problems in the management of infections with methicillin resistant Staphylococcus aureus.
MedLine Citation:
PMID:  16912437     Owner:  NLM     Status:  MEDLINE    
PURPOSE: It is necessary to define the problem of methicillin resistant Staphylococcus aureus (MRSA) in every hospital to evolve control strategies. The objectives of this study were to determine factors influencing the persistence of MRSA in patients with hospital acquired infection and to identify alternate cost effective antibiotics. METHODS: A six month study was carried out for 50 patients with MRSA infection. Treatment modalities and risk factors were determined by a preset protocol. Minimum inhibitory concentration of commonly used antibiotics was determined. RESULTS: The risk factors were prolonged postoperative morbidity, prior antibiotic therapy and emergency admissions. Seventy percent of the isolates were from postoperative cases undergoing emergency surgeries. Isolation was highest during the second week of hospital stay. Emergency admissions had a significantly higher chance of early isolation. Prior treatment with multiple antibiotics in 38% was found to be another major risk factor. Ofloxacin was seen to be efficacious in a small percentage of cases. Rifampicin in combination with ofloxacin and clindamycin were found to be other good alternatives. Ofloxacin was found to be the cheapest and vancomycin the most expensive, for a full course of treatment. CONCLUSIONS: Minimizing risk factors and attention to alternate cost effective combination therapy may ease the problem of management of infections with MRSA.
S Srinivasan; D Sheela; ; R Mathew; J Bazroy; R Kanungo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical microbiology     Volume:  24     ISSN:  0255-0857     ISO Abbreviation:  Indian J Med Microbiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2006-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700903     Medline TA:  Indian J Med Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  182-5     Citation Subset:  IM    
Department of Clinical Microbiology, Pondicherry Institute of Medical Sciences, Pondicherry - 605 014, India.
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MeSH Terms
Anti-Bacterial Agents / pharmacology,  therapeutic use*
Cross Infection / drug therapy,  epidemiology*,  microbiology,  prevention & control
Drug Resistance, Bacterial
Drug Therapy, Combination
Methicillin Resistance*
Microbial Sensitivity Tests
Risk Factors
Staphylococcal Infections / drug therapy,  epidemiology*,  microbiology,  prevention & control
Staphylococcus aureus / drug effects*,  isolation & purification
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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