Document Detail


Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients.
MedLine Citation:
PMID:  21490340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable analysis, predictors of arterial thrombosis included age more than 60 years (P = .03; hazard ratio [HR] = 1.7), thrombosis history (P = .003; HR = 2.1), cardiovascular risk factors including tobacco use, hypertension, or diabetes mellitus (P = .007; HR = 1.9), leukocytosis (> 11 × 10(9)/L; P = .04; HR = 1.7), and presence of JAK2V617F (P = .009; HR = 2.6). In contrast, only male gender predicted venous thrombosis. Platelet count more than 1000 × 10(9)/L was associated with a lower risk of arterial thrombosis (P = .007; HR = 0.4). These associations, except the one with leukocytosis, remained significant (or near significant) when analysis was restricted to JAK2V617F-positive cases. The current study clarifies the contribution of specific disease and host characteristics to the risk of arterial versus venous thrombosis in essential thrombocythemia.
Authors:
Alessandra Carobbio; Juergen Thiele; Francesco Passamonti; Elisa Rumi; Marco Ruggeri; Francesco Rodeghiero; Maria Luigia Randi; Irene Bertozzi; Alessandro M Vannucchi; Elisabetta Antonioli; Heinz Gisslinger; Veronika Buxhofer-Ausch; Guido Finazzi; Naseema Gangat; Ayalew Tefferi; Tiziano Barbui
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2011-04-13
Journal Detail:
Title:  Blood     Volume:  117     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-03     Completed Date:  2011-09-08     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5857-9     Citation Subset:  AIM; IM    
Affiliation:
Ospedali Riuniti di Bergamo, Largo Barozzi 1, Bergamo, Italy.
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MeSH Terms
Descriptor/Qualifier:
Arteries / pathology*
Cardiovascular Diseases / complications
Female
Follow-Up Studies
Humans
Hypertension / complications
Incidence
International Agencies
Janus Kinase 2 / genetics
Male
Middle Aged
Mutation / genetics
Polycythemia Vera / complications
Prognosis
Risk Factors
Survival Rate
Thrombocythemia, Essential / complications*,  therapy
Thrombosis / etiology*,  pathology
Venous Thrombosis / etiology*,  pathology
Chemical
Reg. No./Substance:
EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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