| Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients. | |
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MedLine Citation:
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PMID: 21490340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable analysis, predictors of arterial thrombosis included age more than 60 years (P = .03; hazard ratio [HR] = 1.7), thrombosis history (P = .003; HR = 2.1), cardiovascular risk factors including tobacco use, hypertension, or diabetes mellitus (P = .007; HR = 1.9), leukocytosis (> 11 × 10(9)/L; P = .04; HR = 1.7), and presence of JAK2V617F (P = .009; HR = 2.6). In contrast, only male gender predicted venous thrombosis. Platelet count more than 1000 × 10(9)/L was associated with a lower risk of arterial thrombosis (P = .007; HR = 0.4). These associations, except the one with leukocytosis, remained significant (or near significant) when analysis was restricted to JAK2V617F-positive cases. The current study clarifies the contribution of specific disease and host characteristics to the risk of arterial versus venous thrombosis in essential thrombocythemia. |
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Authors:
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Alessandra Carobbio; Juergen Thiele; Francesco Passamonti; Elisa Rumi; Marco Ruggeri; Francesco Rodeghiero; Maria Luigia Randi; Irene Bertozzi; Alessandro M Vannucchi; Elisabetta Antonioli; Heinz Gisslinger; Veronika Buxhofer-Ausch; Guido Finazzi; Naseema Gangat; Ayalew Tefferi; Tiziano Barbui |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2011-04-13 |
Journal Detail:
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Title: Blood Volume: 117 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-03 Completed Date: 2011-09-08 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 5857-9 Citation Subset: AIM; IM |
Affiliation:
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Ospedali Riuniti di Bergamo, Largo Barozzi 1, Bergamo, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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pathology* Cardiovascular Diseases / complications Female Follow-Up Studies Humans Hypertension / complications Incidence International Agencies Janus Kinase 2 / genetics Male Middle Aged Mutation / genetics Polycythemia Vera / complications Prognosis Risk Factors Survival Rate Thrombocythemia, Essential / complications*, therapy Thrombosis / etiology*, pathology Venous Thrombosis / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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