| Risk factors for alloimmunization in patients with sickle cell anemia. | |
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MedLine Citation:
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PMID: 22249547 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To determine erythrocyte phenotyping in blood donors and patients with sickle cell anemia (SS) treated at Hemocentro of Alagoas and describe the frequency and factors associated with erythrocyte alloimmunization. METHODS: Cross-sectional study with 102 SS patients and 100 blood donors. The following tests were performed: erythrocyte phenotyping, Direct and Indirect antiglobulin test, and detection of irregular antibodies by panel of phenotyped red blood cells. Data were compared by Mann-Whitney, qui-square or Fishers exact tests. Factors associated with alloimmunization were studied by univariate and multiple logistic regression analysis. RESULTS: The most frequent antigens found in patients and blood donors were: c, e, M, s, JK(a). Significant differences were observed between the frequency of the phenotype of patients and donors in regard to antigens s, FY(a) and JK(b). Of 79 transfused patients, 10 presented positive Indirect Coombs. Thirteen alloantibodies were found, 7 of the Rh system, 2 of Kell and 4 were not identified. Factors associated with alloimmunization were the period of time between the last transfusion and the date of the test and more than 10 red blood cell transfusions. Patients who received more than 10 transfusions were 16.39 (95% CI: 2.23-120.59) times more likely to be alloimmunized than patients with fewer transfusions. CONCLUSION: The prevalence of alloimmunization in SS patients was 12.7%, with 70% of antibodies belonging to the Rh and Kell systems. This study shows the importance of performing erythrocyte phenotyping in blood donors and receptors to decrease the risk of alloimmunization. |
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Authors:
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Patrícía Costa Alves Pinto; Josefina Aparecida Pellegrini Braga; Amélia Miyashiro Nunes Dos Santos |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Revista da Associacao Medica Brasileira (1992) Volume: 57 ISSN: 0104-4230 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9308586 Medline TA: Rev Assoc Med Bras Country: - |
Other Details:
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Languages: ENG; POR Pagination: 668-673 Citation Subset: - |
Affiliation:
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Hemocentro de Alagoas, Maceió, AL. |
Vernacular Title:
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Fatores de risco para aloimunização em pacientes com anemia falciforme. |
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