Document Detail


Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening.
MedLine Citation:
PMID:  15696004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine whether demographic characteristics, history of exposure to recognized transmission vehicles, or illness that was compatible with acute toxoplasmosis during gestation identified most mothers of infants with congenital toxoplasmosis. STUDY DESIGN: Mothers of 131 infants and children who were referred to a national study of treatment for congenital toxoplasmosis were characterized demographically and questioned concerning exposure to recognized risk factors or illness. RESULTS: No broad demographic features identified populations that were at risk. Only 48% of mothers recognized epidemiologic risk factors (direct or indirect exposure to raw/undercooked meat or to cat excrement) or gestational illnesses that were compatible with acute acquired toxoplasmosis during pregnancy. CONCLUSION: Maternal risk factors or compatible illnesses were recognized in retrospect by fewer than one half of North American mothers of infants with toxoplasmosis. Educational programs might have prevented acquisition of Toxoplasma gondii by those mothers who had clear exposure risks. However, only systematic serologic screening of all pregnant women at prenatal visits or of all newborn infants at birth would prevent or detect a higher proportion of these congenital infections.
Authors:
Kenneth M Boyer; Ellen Holfels; Nancy Roizen; Charles Swisher; Douglas Mack; Jack Remington; Shawn Withers; Paul Meier; Rima McLeod;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-03-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  564-71     Citation Subset:  AIM; IM    
Affiliation:
Rush University Medical Center, Chicago, Ill, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Female
Humans
Pregnancy
Pregnancy Complications, Parasitic / etiology*
Prenatal Diagnosis*
Risk Factors
Toxoplasmosis / etiology*
Toxoplasmosis, Congenital / diagnosis,  etiology,  prevention & control*
Grant Support
ID/Acronym/Agency:
R01 AI27530/AI/NIAID NIH HHS; TMP R01 AI 27530/MP/OMH OPHS HHS
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 2006 Mar;194(3):907; author reply 907-8   [PMID:  16522442 ]
Am J Obstet Gynecol. 2006 Feb;194(2):589; author reply 590   [PMID:  16458668 ]

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