| Risk of excessive weight gain in epileptic children treated with valproate. | |
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MedLine Citation:
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PMID: 10456757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to identify factors associated with excessive weight gain in children treated with valproate, excluding patients fed by gastrostomy or treated with medications known to affect appetite (eg, stimulants). Weight and height were recorded before treatment and at the time of follow-up; a measure of adiposity, body mass index, was computed and expressed in kg/m2, and weight and height for age were converted to Z-score. Putative risk factors included sex, age at start of treatment, monotherapy at start of treatment, duration of follow-up, mental retardation, seizure type (generalized or partial), etiology (idiopathic or cryptogenic versus remote symptomatic), and dose of valproate. Fifty-five children (30 girls, 25 boys), ranging in age at the start of therapy from 1.8 to 16.9 years were followed for 8.6 to 33.8 months. Forty-three patients had primarily generalized seizures, 34 had idiopathic or cryptogenic epilepsy (including 30 with generalized idiopathic epilepsy), and 18 had mental retardation. Valproate was the first antiepileptic drug for 21 patients, and 43 were on monotherapy at the time of follow-up. Height Z-score decreased significantly in girls but was stable in boys. There was a significant increase in body mass index and in weight Z-score. Body mass index was greater than the 90th percentile for age in 14 patients at the start of treatment and in 20 patients at follow-up. Decrease in height Z-score was significantly correlated with female sex and duration of follow-up. Changes in weight Z-score and body mass index were significantly correlated with initial weight Z-score and initial body mass index, respectively, but not with age at start of therapy, duration of follow-up, sex, seizure type, etiology, dose of valproate, or monotherapy. |
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Authors:
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G P Novak; J Maytal; A Alshansky; L Eviatar; R Sy-Kho; Q Siddique |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 14 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-10-14 Completed Date: 1999-10-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 490-5 Citation Subset: IM |
Affiliation:
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Division of Neurology, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA. gpn325@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / administration & dosage, adverse effects* Body Mass Index Child Child, Preschool Dose-Response Relationship, Drug Epilepsy / drug therapy* Female Follow-Up Studies Humans Infant Male Risk Factors Sex Factors Valproic Acid / administration & dosage, adverse effects* Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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