| Risk of epilepsy in offspring of affected women: association with maternal spontaneous abortion. | |
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MedLine Citation:
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PMID: 11706105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previously, the authors found that risk of spontaneous abortion was increased in the pregnancies of women with epilepsy compared with their same-sex siblings, which could have implications for risk of epilepsy in their offspring. An association between a history of spontaneous abortion in the mother and risk of epilepsy in her live-born offspring may arise through selective loss of fetuses with a genetic susceptibility to epilepsy or through intrauterine environmental factors that may predispose the mother to a spontaneous abortion and to epilepsy in her live-born children. METHOD: The authors examined the relation of a history of spontaneous abortion to the risk of idiopathic or cryptogenic epilepsy in 791 live-born offspring of 385 women with cryptogenic localization-related epilepsy (probands) ascertained from voluntary organizations. A semistructured telephone interview with probands and additional family informants, supplemented by medical record review, was used to obtain information on seizures and other risk factors in probands and relatives. RESULTS: Live-born offspring of women with a history of spontaneous abortion were four or five times as likely to develop epilepsy as were children of women without (12.8% versus 4.7%; rate ratio = 4.6, 95% CI: 2.3-9.0). Cumulative incidence of epilepsy was 21.9% in offspring of women with a history of spontaneous abortion and a family history of epilepsy, compared with 4.7% in offspring of women with neither risk factor. CONCLUSIONS: These results suggest that a history of spontaneous abortion is associated with increased risk of epilepsy in live-born offspring and may be a marker for genetic susceptibility for epilepsy in the mother. |
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Authors:
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N Schupf; R Ottman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology Volume: 57 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-13 Completed Date: 2001-12-18 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1642-9 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA. ns24@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology* Adult Child Epilepsy / epidemiology* Family Health Female Humans Incidence Middle Aged Pregnancy Prevalence Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS020656-13/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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