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Risk of development of acute pancreatitis with pre-existing diabetes: a meta-analysis.
MedLine Citation:
PMID:  22668873     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: It is well established that acute pancreatitis (AP) often causes diabetes mellitus. However, whether pre-existing diabetes is associated with the development of AP remains unknown. To clarify the association of pre-existing diabetes and the development of AP, we carried out a meta-analysis of observational studies. METHODS: A computerized literature search was performed in MEDLINE (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 January 2012. We also searched the reference lists of relevant articles. Summary relative risks with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I. RESULTS: A total of seven articles (10 523 incident cases of AP) were included in this meta-analysis. Analysis of seven studies indicated that, compared with nondiabetic individuals, diabetic individuals had a 92% increased risk of development of AP (95% CI 1.50-2.47). There was significant evidence of heterogeneity among these studies (Pheterogeneity<0.001, I=93.0%). These increased risks were independent of alcohol use, gallstones, and hyperlipidemia. CONCLUSION: Although the current evidence supports a positive link between pre-existing diabetes and an increased risk of development of AP, additional studies, with a perfect design, are required before definitive conclusions can be drawn.
Authors:
Yuzheng Xue; Yingyue Sheng; Hong Dai; Haiyan Cao; Zongliang Liu; Zhaoshen Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-3
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  -     ISSN:  1473-5687     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Gastroenterology, The Third People's Hospital of Wuxi, Jiangsu bDepartment of Gastroenterology, Changhai Hospital of Second Military Medical University, Shanghai, China.
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