| Risk of development of acute pancreatitis with pre-existing diabetes: a meta-analysis. | |
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MedLine Citation:
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PMID: 22668873 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: It is well established that acute pancreatitis (AP) often causes diabetes mellitus. However, whether pre-existing diabetes is associated with the development of AP remains unknown. To clarify the association of pre-existing diabetes and the development of AP, we carried out a meta-analysis of observational studies. METHODS: A computerized literature search was performed in MEDLINE (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 January 2012. We also searched the reference lists of relevant articles. Summary relative risks with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I. RESULTS: A total of seven articles (10 523 incident cases of AP) were included in this meta-analysis. Analysis of seven studies indicated that, compared with nondiabetic individuals, diabetic individuals had a 92% increased risk of development of AP (95% CI 1.50-2.47). There was significant evidence of heterogeneity among these studies (Pheterogeneity<0.001, I=93.0%). These increased risks were independent of alcohol use, gallstones, and hyperlipidemia. CONCLUSION: Although the current evidence supports a positive link between pre-existing diabetes and an increased risk of development of AP, additional studies, with a perfect design, are required before definitive conclusions can be drawn. |
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Authors:
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Yuzheng Xue; Yingyue Sheng; Hong Dai; Haiyan Cao; Zongliang Liu; Zhaoshen Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-3 |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: - ISSN: 1473-5687 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDepartment of Gastroenterology, The Third People's Hospital of Wuxi, Jiangsu bDepartment of Gastroenterology, Changhai Hospital of Second Military Medical University, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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