Document Detail


Risk counselling for family members in bipolar disorder and schizophrenia.
MedLine Citation:
PMID:  23137787     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In bipolar disorder (BD) and schizophrenia (SZ) rare and de novo chromosomal microdeletions and microduplications (CNVs) have strong effects on risk. For de novo CNVs, the risk of BD or SZ is 10% and for deletions of the q11 region on chromosome 22, the risk of either of these disorders is 77%. A not-insignificant minority of BD and SZ patients have these types of event (4-6.5%). Psychotherapeutic intervention may be needed for within-family stigma and conflicts over genetic test results. These findings also raise ethical issues on stigma prevention, population screening, and abortion based on genotype.
Authors:
Elliot S Gershon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  -     ISSN:  1469-5111     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-2     Citation Subset:  -    
Affiliation:
University of Chicago, Chicago, IL, USA.
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