| Risk classification at the time of diagnosis differentially affects the level of residual disease in children with B-precursor acute lymphoblastic leukemia after completion of therapy. | |
| | |
MedLine Citation:
|
PMID: 12801533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have previously reported that children with B-precursor acute lymphoblastic leukemia (ALL) who remained in remission after successfully completing therapy had leukemia cells detectable by polymerase chain reaction (PCR) (N Engl J Med 1997;336(5):317-23). These patients were treated by an institutional protocol (P89-04) that lacked the post-remission intensification features of the contemporary Berlin-Frankfurt-Münster (BFM) based ALL protocols. In this report, we compared residual leukemia levels for patients on the P89-04 (n=15) and BFM-based Children's Cancer Group (CCG) studies (n=23) and for patients stratified according to risk group. Our goal was to establish which risk factors correlated with level of residual disease. Patients enrolled on the CCG protocols had lower levels of residual disease after completion of therapy than the P89-04 patients (P<0.019). Patients with high-risk disease also had lower levels of residual disease than patients with low risk disease (P<0.0001). Three-way analysis including time off treatment, risk group determined by features at presentation, and treatment protocol showed that risk group was the only significant independent variable (P<0.001). |
| | |
Authors:
|
M Fatih Okcu; W Mark Roberts; Dennis A Johnston; Maia V Ouspenskaia; Victor Z Papusha; Mark A Brandt; Theodore F Zipf |
Related Documents
:
|
12105773 - Gemtuzumab ozogamicin (mylotarg) monotherapy for relapsed aml after hematopoietic stem ... 19451503 - Phylloid hypomelanosis and mosaic partial trisomy 13: two cases that provide further ev... 21732093 - Longitudinal observations of serum heparin cofactor ii-thrombin complex in treated muco... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Leukemia research Volume: 27 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2003 Aug |
Date Detail:
|
Created Date: 2003-06-12 Completed Date: 2003-08-08 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
|
Languages: eng Pagination: 743-50 Citation Subset: IM |
Affiliation:
|
Texas Children's Cancer Center, Baylor College of Medicine, 6621 Fannin, CC 1510.00, Houston, TX 77030-2399, USA. mfokcu@txccc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Combined Chemotherapy Protocols
/
therapeutic use* Bone Marrow Examination Genes, Immunoglobulin Humans Neoplasm, Residual* / diagnosis, drug therapy, etiology Polymerase Chain Reaction Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*, drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*, drug therapy Remission Induction Risk Assessment Risk Factors Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Flt-3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast ...
Next Document: The treatment of multiple myeloma with docetaxel (an ECOG study).