Document Detail

Risk of cataract among idiopathic thrombocytopenic purpura patients in the UK general practice research database.
MedLine Citation:
PMID:  19241439     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To estimate the incidence of cataracts in an adult idiopathic thrombocytopenic purpura (ITP) and in a comparable non-ITP population, stratified by age, gender and medication use in order to determine whether the risk of cataracts is greater in ITP patients. METHODS: Retrospective cohort of 745 newly diagnosed ITP patients and 3725 non-ITP subjects who were 18 years of age or older. The study population included patients registered on the General Practice Research Database (GPRD) during the period 1992-2005. ITP patients, identified using Read/Oxmis codes, were matched to five non-ITP patients. The exposure of interest was oral systemic steroid use and the primary outcome was cataracts. RESULTS: The overall incidence rate of cataracts in males was 11.8 per 1000 PY (95%CI: 6.3-20.2) and in females 9.0 per 1000 PY (95%CI: 5.2-14.4). In the non-ITP population these rates were 14.0 per 1000 PY (95%CI: 11.0-17.4) and 8.1 per 1000 PY (95%CI: 6.4-10.1), respectively. In the ITP population, users of oral steroids (OS) had a cataract incidence rate of 14.0 per 1000 PY (95%CI: 8.7-21.4) and non-users 6.0 per 1000 PY (95%CI: 2.8-11.4). In the non-ITP population, these rates were 16.9 per 1000 PY (95%CI: 11.9-23.3) and 9.2 per 1000 PY (95%CI: 7.6-11.0), respectively. OS were associated with an increased risk for cataracts. CONCLUSIONS: The rates of cataract in an adult ITP population are comparable to that in a non-ITP population.
Maurille A Feudjo-Tepie; Susan A Hall; John Logie; Noah J Robinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  18     ISSN:  1099-1557     ISO Abbreviation:  Pharmacoepidemiol Drug Saf     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  380-5     Citation Subset:  IM    
Worldwide Epidemiology, GlaxoSmithKline R & D, Middlesex, UK.
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MeSH Terms
Aged, 80 and over
Cataract / epidemiology,  etiology*
Databases, Factual
Family Practice
Middle Aged
Purpura, Thrombocytopenic, Idiopathic / complications*
Retrospective Studies

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