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Risk of birth defects increased in multiple births.
MedLine Citation:
PMID:  20890935     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Previous studies inconsistently suggest that there may be an association between birth defects and multiple births.
METHODS: Data were obtained from Zhejiang Hospital-Based Birth Defects Surveillance System during 2007 to 2009. There was a total of 545,018 pregnancies, including 537,593 singleton pregnancies, and 7425 multiple pregnancies (14,606 twins and 366 triplets). Odds ratio (OR)and confidence interval (CI) for birth defects were calculated for the singletons and multiple births.
RESULTS: The rate of birth defects in multiple births was 444.16 per 10,000 births versus 266.97 per 10,000 births in singletons (OR, 1.69; 95% CI, 1.57-1.84). A significant risk of birth defects was observed in 9 of 23 categories in multiple births. Both the multiple births and singletons with birth defects exhibited a similar proportion of single malformation, male children, and the mother living in a city. The multiple births with birth defects were delivered earlier (t = 7.90, p < 0.001) at a lower birth weight (t = 17.53, p < 0.001) compared to singletons with birth defects. The proportion of an antenatal diagnosis was higher in singletons compared with multiple births (p < 0.001). The multiple births with birth defects had a higher proportion of live birth and early neonatal death (p < 0.001).
CONCLUSIONS: An increased risk of birth defects in multiple births compared with singletons was confirmed. Birth Defects Research (Part A), 2011. © 2010 Wiley-Liss, Inc.
Xiao-Hui Zhang; Li-Qian Qiu; Jiang-Ping Huang
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Publication Detail:
Type:  Journal Article     Date:  2010-10-01
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  91     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Deparment Of Women's Health, Women's Hospital School Of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
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