Document Detail


Risk-benefit analysis of a hCG-500 kcal reducing diet (cura romana) in females
MedLine Citation:
PMID:  3609673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The British physician A.T.W. Simeons described in 1954 a new method for dieting. He combined a reduction diet (500 kcal per day) with daily injections of the pregnancy hormone human chorionic gonadotropin (hCG) (125 IU i.m.). According to Simeons the patient should not lose more weight during a 4-to-6 weeks' diet than without hCG, but the injections should facilitate to maintain the diet and to lose body weight at specific parts of the body (e.g. hip, belly, thigh). After the first publication various studies conducted with male and female patients analysed the efficacy of the "Cura romana". 10 of these studies showed positive and another 10 studies negative results with regard to hCG-related weight reduction. Two of these studies with positive results were double-blind studies (hCG vs. placebo). Most of them were reports on therapeutical experiences and were not controlled studies. According to these reports the body proportions normalized and the feeling of hunger was tolerable. Four out of 10 studies with negative results were controlled studies (hCG vs. control without hCG), whereas 6 were double-blind studies. These studies showed a significant weight reduction during dieting, but no differences between treatment groups in respect of body weight, body proportions and feeling of hunger. One of them is the only German study conducted by Rabe et al. in 1981 in which 82 randomised premenopausal volunteers had been dieting either with hCG or without hCG injections. In recent publications describing mostly well-documented double-blind studies authors largely reject hCG administration in dieting. Supporters of the hCG diet must prove the efficacy of this method in controlled studies according to the German Drug Law. Until then the opinion of the German steroid toxicology panel is still valid, that hCG is ineffective in dieting and should not be used (Bolt 1982 a, 1982 b).
Authors:
T Rabe; S Richter; L Kiesel; B Runnebaum
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Geburtshilfe und Frauenheilkunde     Volume:  47     ISSN:  0016-5751     ISO Abbreviation:  Geburtshilfe Frauenheilkd     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370732     Medline TA:  Geburtshilfe Frauenheilkd     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  297-307     Citation Subset:  IM    
Vernacular Title:
Risiko-Nutzen-Analyse einer hCG-500-kcal-Reduktionsdiät (Cura romana) bei Frauen.
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MeSH Terms
Descriptor/Qualifier:
Appetite / drug effects
Body Weight / drug effects
Chorionic Gonadotropin / therapeutic use*
Combined Modality Therapy
Diet, Reducing*
Energy Intake / drug effects
Female
Humans
Hunger / drug effects
Injections, Intramuscular
Obesity / therapy*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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