Document Detail

Risk-based classification of hypertension and the role of combination therapy.
MedLine Citation:
PMID:  18174778     Owner:  NLM     Status:  MEDLINE    
The recognition of a continuous relationship between elevated blood pressure (BP) and cardiovascular risk has influenced national and international guidelines for the classification, prevention, and management of hypertension. The most recent report (2003) of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure uses BP thresholds to define categories of normal, prehypertension, and hypertension. A new definition proposed by the Hypertension Writing Group in 2005 offers an approach to diagnosis and management based on global or total risk. Thus, even in the absence of sustained elevations in BP, patients may have a moderate to high risk of vascular events due to the presence of additional cardiovascular risk factors, disease markers, and target organ damage. The 2007 European guidelines continue to classify hypertension based on cutoffs while also placing emphasis on multivariate formulations for cardiovascular risk assessment and goals of therapy. All 3 sets of guidelines acknowledge the necessity of using > or =2 antihypertensive agents to attain BP goals in many patients.
Matthew R Weir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  10     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-12     Citation Subset:  IM    
Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21202, USA.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage
Angiotensin-Converting Enzyme Inhibitors / administration & dosage
Antihypertensive Agents / classification,  therapeutic use*
Calcium Channel Blockers / administration & dosage
Cardiovascular Diseases / etiology,  prevention & control*
Diuretics / administration & dosage
Drug Therapy, Combination
Guidelines as Topic
Hypertension / classification*,  complications,  drug therapy
Receptors, Angiotensin / antagonists & inhibitors
Risk Assessment
Risk Factors
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Diuretics; 0/Receptors, Angiotensin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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