Document Detail


Risk of autoimmune disease: challenges for immunotoxicity testing.
MedLine Citation:
PMID:  19967505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmunity represents a potentially diverse and complex category among the range of adverse outcomes for detection with immunotoxicity testing. For this reason, the risk of autoimmune disease is discussed in this overview chapter with additional mention among the later specific protocol chapters. Improvements in clinical diagnostic capabilities and disease recognition have led to a more accurate picture of the extent of autoimmune diseases across different human populations. While the risk of any single autoimmune disease remains modest when compared with that of lung or heart disease, the cumulative prevalence of autoimmune diseases is both significant and increasing. Autoimmune diseases are usually viewed in the context of the damaged tissue or organ (e.g., as a thyroid, gastrointestinal, cardiovascular or neurological disease). But improved recognition that underlying immune dysfunction can connect the risks for these as well as other diseases is critical for optimizing risk assessment. Since autoimmune diseases are chronic in nature with many first appearing in children or in young adults, these diseases exert a serious impact on both health care costs and quality of life. This chapter provides a discussion of the issues that should be considered with immunotoxicity testing for risk of autoimmunity.
Authors:
Rodney R Dietert; Janice M Dietert; Jerrie Gavalchin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  598     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Autoimmune Diseases / immunology*,  physiopathology
Autoimmunity / immunology*
Child
Child, Preschool
Environmental Exposure / adverse effects
Environmental Pollutants / toxicity
Female
Humans
Hypersensitivity / immunology*
Immunologic Tests / methods*
Infant
Male
Middle Aged
Risk Factors
Sex Factors
T-Lymphocytes / immunology
Toxicity Tests / methods*
Young Adult
Chemical
Reg. No./Substance:
0/Environmental Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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