| Risk assignment in childhood brain tumors: the emerging role of molecular and biologic classification. | |
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MedLine Citation:
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PMID: 11822983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain tumors as a group are the most common solid tumors of childhood and currently have the highest mortality rate. A major emphasis has historically been placed on stratifying therapy for these tumors based on histologic and clinical prognostic factors. However, with the increasing application of molecular approaches to refine the categorization of these tumors, it has become apparent that histologically comparable lesions may exhibit diverse patterns of gene expression and genomic alterations, which may correspond with important prognostic distinctions. This paper summarizes these observations and discusses how they are being applied in a preliminary fashion as a foundation for risk-adapted stratification of childhood brain tumor therapy. |
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Authors:
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Ian F Pollack; Jaclyn Biegel; Allan Yates; Ronald Hamilton; Sydney Finkelstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current oncology reports Volume: 4 ISSN: 1523-3790 ISO Abbreviation: Curr Oncol Rep Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-01 Completed Date: 2002-04-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100888967 Medline TA: Curr Oncol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 114-22 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Children"s Hospital of Pittsburgh, Main Tower, Floor 3, Room 3705, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. pollaci@chplink@chp.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms*
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classification*,
epidemiology,
genetics* Child, Preschool Gene Expression Regulation, Neoplastic Genetic Markers* Glioma / classification, genetics Humans Medulloblastoma / classification, genetics Neuroectodermal Tumors, Primitive / classification, genetics Prognosis Risk Factors Time Factors Tumor Markers, Biological* |
| Grant Support | |
ID/Acronym/Agency:
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CA13539/CA/NCI NIH HHS; CA46274/CA/NCI NIH HHS; NS01810/NS/NINDS NIH HHS; NS37704/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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