Document Detail

Risk assessment of the organophosphate pesticides isazofos and pyraclofos using a 21-day dietary toxicity study in Japanese quail.
MedLine Citation:
PMID:  17629558     Owner:  NLM     Status:  MEDLINE    
Six-week-old male and female Japanese quails (Coturnix japonica) received two organophosphate pesticides, isazofos and pyraclofos, for a 21-day dietary toxicity test, based on the OECD workshop report. During the treatment period, body weight and food consumption of the quail decreased with exposure to either isazofos or pyraclofos. Using the up-and-down procedure to determine the 50% mortality value, we found that the 21-day LC(50) of isazofos and pyraclofos were 40 and 87 mg/kg body weight, respectively. Ataxia, salivation, diarrhea, ruffled feathers, and convulsions at a dead point were observed with both pesticides. The tips of the villi were necrotic in the high dosage groups of isazofos- and pyraclofos-treated quail. Based on these results, body weight, food consumption, clinical signs, and histopathological findings may be useful parameters for detecting the dietary toxicity associated with isazofos and pyraclofos exposure. In addition, Japanese quail could be an excellent bird model for monitoring the toxicological risks of pesticides in Korea.
Seung-Hyeok Seok; Jong-Hwan Park; Sun-A Cho; Dong-Jae Kim; Bo-Kyoung Bae; Jae-Hak Park
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-16
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  71     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Department of Laboratory Animal Medicine, KRF Zoonotic Disease Priority Research Institute, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
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MeSH Terms
Animal Feed
Diet / veterinary
Dose-Response Relationship, Drug
Molecular Structure
Organothiophosphorus Compounds / administration & dosage,  chemistry,  toxicity*
Pesticides / toxicity*
Thiophosphoric Acid Esters / administration & dosage,  chemistry,  toxicity*
Reg. No./Substance:
0/Organothiophosphorus Compounds; 0/Pesticides; 0/Thiophosphoric Acid Esters; 42509-80-8/isazophos; 89784-60-1/pyraclofos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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