Document Detail

Risk assessment of mixtures of pesticides. Current approaches and future strategies.
MedLine Citation:
PMID:  19782118     Owner:  NLM     Status:  MEDLINE    
The risk assessment of pesticide residues in food is based on toxicological evaluation of the single compounds and no internationally accepted procedure exists for evaluation of cumulative exposure to multiple residues of pesticides in crops, except for a few groups of pesticides sharing a group ADI. However, several attempts have been suggested during the last decade. This paper gives an overview of the various approaches. It is of paramount importance to consider whether there will be either no interaction or interaction between the compounds in the mixture. When there are no interactions several approaches are available for the risk assessment of mixtures of pesticides. However, no single simple approach is available to judge upon potential interactions at the low doses that humans are exposed to from pesticide residues in food. In these cases, PBTK models could be useful as tools to assess combined tissue doses and to help predict potential interactions including thresholds for such effects. This would improve the quality of the risk assessment.
Trine Klein Reffstrup; John Christian Larsen; Otto Meyer
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-24
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  56     ISSN:  1096-0295     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-92     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Inc. All rights reserved.
National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.
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MeSH Terms
Environmental Monitoring / methods*
Environmental Pollutants / analysis,  toxicity
Food Contamination / analysis,  prevention & control*
Pesticides / analysis,  chemistry*,  poisoning*
Risk Assessment
Reg. No./Substance:
0/Environmental Pollutants; 0/Pesticides

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