| Risk assessment of leukaemia and occupational exposure to benzene. | |
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MedLine Citation:
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PMID: 2611155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental toxicological studies have offered clear evidence that benzene induces haematopoietic neoplasms, and it is generally accepted that exposure to benzene is a risk factor for leukaemia, in particular for acute non-lymphatic leukaemia. Quantitative aspects of benzene risk assessment are still a matter of controversy, however. In several risk assessments an estimated 50 deaths from leukaemia per 1000 deaths would arise from exposures to benzene of 10 ppm during a working life of 30 years. The assessment presented in this paper leads to lower estimates, which are more in agreement with the weak toxicological data. Furthermore, an approach is presented to incorporate the results of low exposure epidemiological studies into the process of quantitative risk assessment. |
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Authors:
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G M Swaen; J M Meijers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of industrial medicine Volume: 46 ISSN: 0007-1072 ISO Abbreviation: Br J Ind Med Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-02-26 Completed Date: 1990-02-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370637 Medline TA: Br J Ind Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 826-30 Citation Subset: IM |
Affiliation:
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Department of Occupational Health and Toxicology, University of Limburg, Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzene
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adverse effects* Humans Leukemia, Myeloid, Acute / chemically induced*, epidemiology, mortality Male Occupational Diseases / chemically induced* Risk Factors |
| Chemical | |
Reg. No./Substance:
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71-43-2/Benzene |
| Comments/Corrections | |
Comment In:
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Br J Ind Med. 1990 Oct;47(10):717-8
[PMID:
2223665
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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