Document Detail

Risk assessment in neonatal early onset sepsis.
MedLine Citation:
PMID:  23177799     Owner:  NLM     Status:  MEDLINE    
The incidence of neonatal early onset sepsis has declined with the widespread use of intrapartum antibiotic therapies, yet early onset sepsis remains a potentially fatal condition, particularly among very low birth-weight infants. Clinical signs of neonatal infection are nonspecific and may be absent in the immediate postnatal period. Maternal and infant clinical characteristics, as well as infant laboratory values, have been used to identify newborns at risk and to administer empiric antibiotic therapy to prevent progression to more severe illness. Such approaches result in the evaluation of approximately 15% of asymptomatic term and late preterm infants and of nearly all preterm infants. The development of multivariate predictive models may provide more accurate methods of identifying newborns at highest risk and allow for more limited newborn antibiotic exposures.
Sagori Mukhopadhyay; Karen M Puopolo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  36     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-05-24     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  408-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Division of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Age of Onset
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis / methods*
Asymptomatic Diseases
Infant, Newborn
Infant, Newborn, Diseases* / diagnosis,  epidemiology,  microbiology,  physiopathology,  prevention & control
Infant, Premature
Infant, Very Low Birth Weight
Models, Statistical
Perinatal Care / methods,  organization & administration
Policy Making
Risk Assessment* / methods,  organization & administration
Risk Factors
Sepsis* / diagnosis,  epidemiology,  microbiology,  physiopathology,  prevention & control
Severity of Illness Index
Streptococcus agalactiae / drug effects,  isolation & purification
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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